Results 61 to 70 of about 4,323,813 (404)

Trinity: reconstructing a full-length transcriptome without a genome from RNA-Seq data

Nature Biotechnology, 2011
Massively parallel sequencing of cDNA has enabled deep and efficient probing of transcriptomes. Current approaches for transcript reconstruction from such data often rely on aligning reads to a reference genome, and are thus unsuitable for samples with a
M. Grabherr, B. Haas, M. Yassour, J. Levin, Dawn A Thompson, I. Amit, Xian Adiconis, Lin Fan, R. Raychowdhury, Qiandong Zeng, Zehua Chen, E. Mauceli, N. Hacohen, A. Gnirke, Nicholas Rhind, F. Di Palma, B. Birren, C. Nusbaum, K. Lindblad-Toh, N. Friedman, A. Regev   +20 more
semanticscholar   +1 more source

The neglected genome [PDF]

EMBO reports, 2012
The mitochondrial genome, though tiny, is vital to life. Modern high‐throughput investigations should pay closer attention to this minute genetic treasure trove.
Pesole G, Allen JF, Lane N, Martin W, Rand DM, Schatz G, Saccone C   +6 more
openaire   +6 more sources

Staphylococcus saccharolyticus Isolated From Blood Cultures and Prosthetic Joint Infections Exhibits Excessive Genome Decay

Frontiers in Microbiology, 2019
The slow-growing, anaerobic, coagulase-negative species Staphylococcus saccharolyticus is found on human skin and in clinical specimens but its pathogenic potential is unclear.
Holger Brüggemann, Anja Poehlein, Elzbieta Brzuszkiewicz, Carsten Scavenius, Jan J. Enghild, Munir A. Al-Zeer, Volker Brinkmann, Anders Jensen, Bo Söderquist   +8 more
doaj   +1 more source

Evolution of genome size in asexual populations

, 2015
Genome sizes have evolved to vary widely, from 250 bases in viroids to 670 billion bases in amoeba. This remarkable variation in genome size is the outcome of complex interactions between various evolutionary factors such as point mutation rate ...
Adami, Christoph, Gupta, Aditi, LaBar, Thomas, Miyagi, Michael   +3 more
core   +1 more source

Draft Genome Sequence of Frankia sp. Strain CN3, an Atypical, Noninfective (Nod–) Ineffective (Fix–) Isolate from Coriaria nepalensis [PDF]

, 2013
We report here the genome sequence of Frankia sp. strain CN3, which was isolated from Coriaria nepalensis. This genome sequence is the first from the fourth lineage of Frankia, strains of which are unable to reinfect actinorhizal plants.
Beauchemin, Nicholas, Bruce, David, Chain, Patrick, Chen, Amy, Deshpande, Shweta, Detter, Chris, Furnholm, Teal, Ghodhbane-Gtari, Faten, Goodwin, Lynne, Gtari, Maher, Han, Cliff, Han, James, Huntemann, Marcel, Ivanova, Natalia, Kyrpides, Nikos, Land, Miriam L., Markowitz, Victor, Mavrommatis, Kostas, Nolan, Matt, Nouioui, Imen, Pagani, Ioanna, Pati, Amrita, Pitluck, Sam, Santos, Catarina L., Sen, Arnab, Sur, Saubashya, Szeto, Ernest, Tavares, Fernando, Teshima, Hazuki, Thakur, Subarna, Tisa, Louis S., Wall, Luis, Walston Davenport, Karen, Woyke, Tanja   +33 more
core   +2 more sources

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]

, 2020
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David, Beliveau, Brian, Cavalli, Giacomo, KARPEN, Gary H., Lee, Yuh, Martins, Nuno, Ogiyama, Yuki, Wu, C-Ting   +7 more
core   +2 more sources

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

Genome Biology
Background The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease.
The Critical Assessment of Genome Interpretation Consortium
doaj   +1 more source

Diversity of Vibrio navarrensis Revealed by Genomic Comparison: Veterinary Isolates Are Related to Strains Associated with Human Illness and Sewage Isolates While Seawater Strains Are More Distant

Frontiers in Microbiology, 2017
Strains of Vibrio navarrensis are present in aquatic environments like seawater, rivers, and sewage. Recently, strains of this species were identified in human clinical specimens. In this study, V.
Keike Schwartz, Cindy Kukuc, Nadja Bier, Karin Taureck, Jens A. Hammerl, Eckhard Strauch   +5 more
doaj   +1 more source

Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes

Frontiers in Genetics, 2022
Vertebrates need suitable lipases to digest lipids for the requirement of energy and essential nutrients; however, the main digestive lipase genes of fishes have certain controversies. In this study, two types of digestive lipase genes (pancreatic lipase
Shu-Lin Tang, Shu-Lin Tang, Xu-Fang Liang, Xu-Fang Liang, Shan He, Shan He, Ling Li, Ling Li, Muhammad Shoaib Alam, Muhammad Shoaib Alam, Jiaqi Wu, Jiaqi Wu   +11 more
doaj   +1 more source

Unambiguosly expressing expectations about the content of prokaryotic genomes [PDF]

arXiv, 2023
In recent years, the sequencing, assembling and annotation of prokaryotic genomes has become increasingly easy and cheap. Thus it becomes increasingly feasible and interesting to perform comparative genomics analyses of new genomes to those of related organisms.
arxiv