Results 61 to 70 of about 4,660,063 (378)

Advances in Cryptococcus genomics: insights into the evolution of pathogenesis

Memorias do Instituto Oswaldo Cruz, 2018
Cryptococcus species are the causative agents of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals. Initial work on the molecular epidemiology of this fungal pathogen utilized genotyping approaches to describe ...
Christina A Cuomo, Johanna Rhodes, Christopher A Desjardins   +2 more
doaj   +1 more source

Genome sequence of a novel alloherpesvirus isolated from glass catfish (Kryptopterus bicirrhis) [PDF]

, 2018
The 149,343-bp genome of silurid herpesvirus 1, which was isolated in Thailand from glass catfish, was sequenced. The genome was most closely related to that of ictalurid herpesvirus 2, which infects black bullhead catfish. To our knowledge, this was the
Davison, Andrew J., Henriquez, Rachel N., Kanchanakhan, Somkiat, Polchana, Jaree, Subramaniam, Kuttichantran, Waltzek, Thomas B.   +5 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Validation of a guidelines-based digital tool to assess the need for germline cancer genetic testing

Hereditary Cancer in Clinical Practice
Background Efficient and scalable solutions are needed to identify patients who qualify for germline cancer genetic testing. We evaluated the clinical validity of a brief, patient-administered hereditary cancer risk assessment digital tool programmed to ...
Callan D. Russell, Ashley V. Daley, Durand R. Van Arnem, Andi V. Hila, Kiley J. Johnson, Jill N. Davies, Hanah S. Cytron, Kaylene J. Ready, Cary M. Armstrong, Mark E. Sylvester, Colleen A. Caleshu   +10 more
doaj   +1 more source

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? [PDF]

, 2004
During virus assembly, all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer.
Liang, Chen, Russell, Rodney S, Wainberg, Mark A   +2 more
core   +3 more sources

CADD: predicting the deleteriousness of variants throughout the human genome

Nucleic Acids Res., 2018
Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders.
Philipp Rentzsch, D. Witten, G. Cooper, J. Shendure, Martin Kircher   +4 more
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Expression of concern for global biomedical research by the human genome organization (HUGO)

Human Genomics
Cuts to US science funding will stall advances in genomics affecting public health, rare disease and cancer diagnostics and therapeutics in the US and around the world.
Ada Hamosh, Fabiana Arzuaga, Karen B. Avraham, Zilfalil Bin Alwi, Anne Bowcock, Sir John Burn, Piero Carninci, Collet Dandara, Iscia Lopes-Cendes, Leon Mutesa, Partha P. Majumder, Juergen K.V. Reichardt, Joris A. Veltman   +12 more
doaj   +1 more source

Complete genome sequence of Spirosoma linguale type strain (1). [PDF]

, 2010
Spirosoma linguale Migula 1894 is the type species of the genus. S. linguale is a free-living and non-pathogenic organism, known for its peculiar ringlike and horseshoe-shaped cell morphology. Here we describe the features of this organism, together with
Brettin, Thomas, Bristow, Jim, Bruce, David, Chain, Patrick, Chang, Yun-Juan, Chen, Amy, Chen, Feng, Cheng, Jan-Fang, Copeland, Alex, Detter, John C, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Lail, Kathleen, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Nolan, Matt, Ovchinnikova, Galina, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Saunders, Elizabeth, Schütze, Andrea, Sikorski, Johannes, Tice, Hope, Tindall, Brian J   +36 more
core   +1 more source

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Journal of Medical Virology, 2020
The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health.
Yu Chen, Qianyun Liu, D. Guo
semanticscholar   +1 more source