Results 201 to 210 of about 1,550,449 (243)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

PGAP2: A comprehensive toolkit for prokaryotic pan-genome analysis based on fine-grained feature networks. [PDF]

open access: yesNat Commun
Bu C   +11 more
europepmc   +1 more source

Whole genome analysis of carbapenem resistant <i>Acinetobacter baumannii</i> isolates from healthcare-associated infections in Dakar, Senegal. [PDF]

open access: yesNew Microbes New Infect
Ndiaye I   +12 more
europepmc   +1 more source

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