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Cancer Genome Analysis Informatics
2010The analysis of cancer genomes has benefited from the advances in technology that enable data to be generated on an unprecedented scale, describing a tumour genome's sequence and composition at increasingly high resolution and reducing cost. This progress is likely to increase further over the coming years as next-generation sequencing approaches are ...
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Comparative Genomic Analysis Using the UCSC Genome Browser
2007Comparative analysis of DNA sequence from multiple species can provide insights into the function and evolutionary processes that shape genomes. The University of California Santa Cruz (UCSC) Genome Bioinformatics group has developed several tools and methodologies in its study of comparative genomics, many of which have been incorporated into the UCSC
Donna, Karolchik +8 more
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Genomic Southern Blot Analysis
2013This chapter describes a detailed protocol for genomic Southern blot analysis which can be used to detect transgene or endogenous gene sequences in cereal genomes. The protocol follows a standard approach that has been shown to generate high-quality results: size fractionation of genomic DNA; capillary transfer to a nylon membrane; hybridization with a
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Genomic analysis of whole-genome resequencing
Whole-genome resequencing data were generated to characterize the genetic diversity, population structure, and selective sweeps of the Wannan Yellow-feathered chicken, a representative Chinese indigenous breed. The project provides genomic insights into breed differentiation and establishes a SNP panel for accurate breed identification and conservationopenaire +1 more source
Genome partitioning and whole-genome analysis.
Advances in genetics, 2001Standard DNA marker-based approaches to mapping genes that influence complex traits typically consider a limited number of hypotheses. Most of these hypotheses concentrate on the effect of a single individual locus (or relatively few loci) on the trait of interest. Although of tremendous importance scientifically, such hypotheses do not accommodate the
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