Results 261 to 270 of about 300,948 (293)
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
Advanced Science, EarlyView.This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang +13 more
wiley +1 more source
IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation
Advanced Science, EarlyView.LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu +10 more
wiley +1 more source
Annotation of the Drosophila genome [PDF]
Nature, 2001 The publication of the genome of the fruitfly Drosophila by Celera Genomics last year generated considerable excitement1. The initial release predicted 14,226 proteins, including about 550 that arise as the result of alternative splicing1. Here we compare the annotation of the Celera Drosophila genome with known protein sequences lodged in a databank ...
Aviv Bergman +2 more
openaire +2 more sources
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2021
In the last decade, the high-throughput and relatively low cost of short-read sequencing technologies have revolutionized prokaryotic genomics. This has led to an exponential increase in the number of bacterial and archaeal genome sequences available, as well as corresponding increase of genome assembly and annotation tools developed.
Jeffrey A. Kimbrel +2 more
openaire +3 more sources
In the last decade, the high-throughput and relatively low cost of short-read sequencing technologies have revolutionized prokaryotic genomics. This has led to an exponential increase in the number of bacterial and archaeal genome sequences available, as well as corresponding increase of genome assembly and annotation tools developed.
Jeffrey A. Kimbrel +2 more
openaire +3 more sources
2019
Genome annotation makes it possible to identify the coding and non-coding regions of a genome, such as exons-introns, regulatory elements, repeats as well as gene functions and locations. The newly developed eggplant genome sequence (see Chap. 7) was masked using RepeatMasker, by combining homology-based and de novo approaches, and ~73% of the eggplant
Sergio Lanteri, Lorenzo Barchi
openaire +3 more sources
Genome annotation makes it possible to identify the coding and non-coding regions of a genome, such as exons-introns, regulatory elements, repeats as well as gene functions and locations. The newly developed eggplant genome sequence (see Chap. 7) was masked using RepeatMasker, by combining homology-based and de novo approaches, and ~73% of the eggplant
Sergio Lanteri, Lorenzo Barchi
openaire +3 more sources
Plant Physiology and Biochemistry, 2001
85 ref.
Aubourg, Sebastien, Rouzé, Pierre
openaire +2 more sources
85 ref.
Aubourg, Sebastien, Rouzé, Pierre
openaire +2 more sources
2016
The dynamic structure and functions of genomes are being revealed simultaneously with the progress of technologies and researches in genomics. Evidence indicating genome regional characteristics (genome annotations in a broad sense) provide the basis for further analyses.
Imad, Abugessaisa +2 more
openaire +2 more sources
The dynamic structure and functions of genomes are being revealed simultaneously with the progress of technologies and researches in genomics. Evidence indicating genome regional characteristics (genome annotations in a broad sense) provide the basis for further analyses.
Imad, Abugessaisa +2 more
openaire +2 more sources
2008
The dynamic structure and functions of genomes are being revealed simultaneously with the progress of genome analyses. Evidence indicating genome regional characteristics (genome annotations in a broad sense) provide the basis for further analyses. Target listing and screening can be effectively performed in silico using such data.
Hideya, Kawaji, Yoshihide, Hayashizaki
openaire +2 more sources
The dynamic structure and functions of genomes are being revealed simultaneously with the progress of genome analyses. Evidence indicating genome regional characteristics (genome annotations in a broad sense) provide the basis for further analyses. Target listing and screening can be effectively performed in silico using such data.
Hideya, Kawaji, Yoshihide, Hayashizaki
openaire +2 more sources
Current Opinion in Structural Biology, 2000
The Genome Annotation Assessment Project tested current methods of gene identification, including a critical assessment of the accuracy of different methods. Two new databases have provided new resources for gene annotation: these are the InterPro database of protein domains and motifs, and the Gene Ontology database for terms that describe the ...
Michael Ashburner +2 more
openaire +3 more sources
The Genome Annotation Assessment Project tested current methods of gene identification, including a critical assessment of the accuracy of different methods. Two new databases have provided new resources for gene annotation: these are the InterPro database of protein domains and motifs, and the Gene Ontology database for terms that describe the ...
Michael Ashburner +2 more
openaire +3 more sources