Results 91 to 100 of about 1,632,775 (273)
Is abundant A-to-I RNA editing primate-specific? [PDF]
Trends in Genetics, Vol. 21, 77-81 (2005), 2004 A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly.
arxiv +1 more source
Artificial and Natural Genetic Information Processing [PDF]
, 2017 Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core
BMC BioinformaticsBackground Tracking of Insertions and DEletions (TIDE) analysis, which computationally deconvolves capillary sequencing data derived from the DNA of bulk or clonal cell populations to estimate the efficiency of targeted mutagenesis by programmable ...
Kazuki Nakamae +5 more
doaj +1 more source
Microorganisms, 2023 The aim of this work was to study the genetic diversity of the gonococcal genetic island (GGI) responsible for the type IV secretion system (T4SS) and the association of a functionally active GGI with antimicrobial resistance. An analysis of the GGI in a
Dmitry Kravtsov +2 more
doaj +1 more source
Unified theory of human genome reveals a constrained spatial chromosomal arrangement in interphase nuclei [PDF]
, 2015 We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across all pairs of chromosomes in the genome to derive an extrinsic parameter called effective gene density.
arxiv +1 more source
Proceedings, 2020 Current antiretroviral therapy efficiently suppresses viral replication but cannot eliminate latent HIV reservoirs. Moreover, the associated high costs, side effects, and drug resistance have stimulated a need for the development of alternative methods ...
Aleksandra Maslennikova +3 more
doaj +1 more source
Genome Editing – Interdisziplinäre Technikfolgenabschätzung [PDF]
, 2019 ISBN:978-3-7281-3981 ...
Lang, Alexander +11 more
openaire +11 more sources
Student faculty forum: Human genome editing [PDF]
, 2017 Join us in discussion of the science behind the revolution in reading and manipulating the genome, possibilities for the future, and the ethical and legal issues in the field of genomics. Special guests include: Gustavo Mostoslavsky, Assoc.
Boston University Howard Thurman Center for Common Ground
core
Machine Learning Applications for Therapeutic Tasks with Genomics Data [PDF]
arXiv, 2021 Thanks to the increasing availability of genomics and other biomedical data, many machine learning approaches have been proposed for a wide range of therapeutic discovery and development tasks. In this survey, we review the literature on machine learning applications for genomics through the lens of therapeutic development. We investigate the interplay
arxiv
Frontiers in Genetics, 2020 The NETO2 gene (neuropilin and tolloid-like 2) encodes a protein that acts as an accessory subunit of kainate receptors and is predominantly expressed in the brain.
Maria S. Fedorova +14 more
doaj +1 more source