Results 71 to 80 of about 1,533,500 (299)

Genome editing for improvement sunflower oil quality – possibilities and problems

, 2019
Modern sunflower breeding dedicate a great attention in altering oil quality. Sunflower oil gain importance due to the frequent transition to the Mediterranean dict (using oils tich in oleic acid), and the requirements of biodiesel industry, preferring
Grahovac, Nada, Cvejić, Sandra, Gvozdenac, Sonja, Ćuk, Nemanja, Radanović, Aleksandra, Jocić, Siniša, Jocković, Milan, Miladinović, Dragana   +7 more
core   +1 more source

CRISPR-Cpf1: A New Tool for Plant Genome Editing

, 2017
peer reviewedClustered regularly interspaced palindromic repeats (CRISPR)-CRISPR-associated proteins (CRISPR-Cas), a groundbreaking genome-engineering tool, has facilitated targeted trait improvement in plants. Recently, CRISPR-CRISPR from Prevotella and
Mahfouz, Magdy M., Mansoor, Shahid, Shahid Mansoor, Magdy M. Mahfouz, Syed-Shan-e-Ali, Zaïdi, Syed Shan-e-Ali Zaidi, Zaidi, Syed Shan-e-Ali   +6 more
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Molecular characterization of genome-edited Vitis vinifera cv. Chardonnay plants to improve biotic stress resilience

, 2022
reservedNella presente tesi sono state ottenute e caratterizzate piante di Vitis vinifera cv Chardonnay editate mediante Genome Editing. Nello specifico tale editing prevede il silenziamento di geni di suscettibilità nei confronti di Erysiphe Necator ...
DEL PIOLUOGO, RICCARDO
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The evolving landscape of hybrid viral vector architectures: a persisting niche

Frontiers in Bioengineering and Biotechnology
The development of hybrid viral vectors was historically driven by the need to overcome inherent limitations of individual viral platforms, including restricted payload capacity, narrow tropism, and limited control over genomic persistence.
Konstantin Kochergin-Nikitsky, Svetlana Smirnikhina   +1 more
doaj   +1 more source

Editing the Mitochondrial Genome

New England Journal of Medicine, 2020
Mending Mitochondrial Mutation For most patients with mitochondrial disorders, most of which are caused by mutations in genes in the mitochondrial genome, only symptomatic treatment is available.
Maria Falkenberg, Michio Hirano
openaire   +3 more sources

History of genome editing in yeast [PDF]

Yeast, 2018
AbstractFor thousands of years humans have used the budding yeast Saccharomyces cerevisiae for the production of bread and alcohol; however, in the last 30–40 years our understanding of the yeast biology has dramatically increased, enabling us to modify its genome. Although S.
Marcin G. Fraczek, Samina Naseeb, Daniela Delneri   +2 more
openaire   +3 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source