Results 51 to 60 of about 1,457,553 (300)

Extracellular vesicle-based delivery to airway basal cells for durable gene therapy in cystic fibrosis

Frontiers in Bioengineering and Biotechnology
Airway basal cells are an appealing target for durable genetic therapy in cystic fibrosis because they are long-lived stem/progenitor cells that maintain and regenerate the pseudostratified airway epithelium.
Anastasiia Ivleva, Anna Demchenko, Svetlana Smirnikhina   +2 more
doaj   +1 more source

Whole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis

Experimental and Molecular Medicine, 2018
Stomach cancer: DNA methylation of hormone receptor genes A sequencing study reveals abnormal changes to DNA that set the stage for stomach cancer development.
Hee-Jin Kim, Tae-Wook Kang, Keeok Haam, Mirang Kim, Seon-Kyu Kim, Seon-Young Kim, Sang-Il Lee, Kyu-Sang Song, Hyun-Yong Jeong, Yong Sung Kim   +9 more
doaj   +1 more source

Cell Surface-Expressed GPI-Anchored Peptides from the CHR Domain of gp41 Are Potent Inhibitors of HIV-1 Fusion

Proceedings, 2020
Current antiretroviral therapy efficiently suppresses viral replication but cannot eliminate latent HIV reservoirs. Moreover, the associated high costs, side effects, and drug resistance have stimulated a need for the development of alternative methods ...
Aleksandra Maslennikova, Dmitriy Komkov, Anastasia Zotova, Dmitriy Mazurov   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genome Editing in iPSC-Based Neural Systems: From Disease Models to Future Therapeutic Strategies [PDF]

, 2021
Therapeutic advances for neurological disorders are challenging due to limited accessibility of the human central nervous system and incomplete understanding of disease mechanisms.
Rossignoli, Giada, Kurian, MA, Ferrini, Arianna, Ferrini, A, McTague, A, Rossignoli, G, Barral, S, McTague, Amy, Kurian, Manju A, Barral, Serena   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

CRISPR-mediated genome editing of wheat for enhancing disease resistance [PDF]

Wheat is cultivated across diverse global environments, and its productivity is significantly impacted by various biotic stresses, most importantly but not limited to rust diseases, Fusarium head blight, wheat blast, and powdery mildew.
Achary, V.M.M., Waites, J.O., Hearne, S., David, E.S., Bandyopadhyay, A.   +4 more
core   +1 more source

Exome-wide association study of bleeding events in patients receiving direct oral anticoagulants

Science Progress
Background Direct oral anticoagulants (DOACs) are first-line medications for stroke prevention in non-valvular atrial fibrillation (AF). However, variability in drug response poses risks of hemorrhagic or thromboembolic events.
Dmitry A Sychev, Anastasiia A Buianova, Sherzod P Abdullaev, Karin B Mirzaev, Vera A Belova, Anna O Shmitko, Valery V Cheranev, Oleg N Suchalko, Lyudmila V Fedina, Svetlana V Batyukina, Natalia A Shatalova, Pavel O Bochkov, Sergey V Glagolev, Denis V Rebrikov, Dmitriy O Korostin   +14 more
doaj   +1 more source

Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus

Viruses, 2022
Influenza A virus (IAV) causes a respiratory infection that affects millions of people of different age groups and can lead to acute respiratory distress syndrome.
Daria Prokhorova, Natalya Zhukova (Eschenko), Anna Lemza, Mariia Sergeeva, Rinat Amirkhanov, Grigory Stepanov   +5 more
doaj   +1 more source