Results 31 to 40 of about 1,457,553 (300)

Strategies for Efficient Gene Editing in Protoplasts of Solanum tuberosum Theme: Determining gRNA Efficiency Design by Utilizing Protoplast

, 2022
Potato (Solanum tuberosum) is a highly diverse tetraploid crop. Elite cultivars are extremely heterozygous with a high prevalence of small length polymorphisms (indels) and single nucleotide polymorphisms (SNPs) within and between cultivars, which must ...
Kieu Phuong, Nam,, Sveriges lantbruksuniversitet., Lenman, Marit,, Andreasson, Erik,   +3 more
core   +1 more source

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Nature Communications, 2022
Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin, Rusen Lu, Changchang Xin, Yuhong Wang, Xinyu Ling, Dong Li, Weiwei Zhang, Mengzhu Liu, Wutao Xie, Lingyun Kong, Wen Si, Ping Wei, Bingbing Xiao, Hsiang-Ying Lee, Tao Liu, Jiazhi Hu   +15 more
doaj   +1 more source

Precision genome editing [PDF]

Nature Methods, 2018
A machine learning model predicts the genotype of CRISPR–Cas9 gene editing products, thereby enabling precise, template-free correction of disease-associated mutations.
openaire   +2 more sources

Breakthrough to genome editing [PDF]

Science, 2015
A, T, G, C: the alphabet code for the nucleotides that are the building blocks of life. Minor, but consequential, changes in this DNA coding can change gene function. Researchers have long sought better ways to edit the genetic code in cultured cells and laboratory organisms to silence, activate, or change targeted genes to gain a better ...
openaire   +2 more sources

GENT2: an updated gene expression database for normal and tumor tissues

BMC Medical Genomics, 2019
Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park, Byoung-Ha Yoon, Seon-Kyu Kim, Seon-Young Kim   +3 more
doaj   +1 more source

The hallmarks of dietary intervention-resilient gut microbiome

npj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko, Vera E. Odintsova, Anastasia Revel-Muroz, Alexander V. Tyakht   +3 more
doaj   +1 more source

Genome-wide analysis of differential RNA editing in epilepsy [PDF]

, 2017
The recoding of genetic information through RNA editing contributes to proteomic diversity, but the extent and significance of RNA editing in disease is poorly understood.
Michael R. Johnson, Van Eyll, J, Ko, Jeong-Hun, Shkura, Kirill, Sarah R. Langley, Kaminski, RM, KO, J-H, Mazzuferi, Manuela, Ko, J.-H, Langley, Sarah R., Foerch, P, Danis, Bénédicte, Delahaye-Duriez, Andree, Srivastava, P.K, Kaminski, Rafal M., Behmoaras, Jacques, Jeong-Hun Ko, Rotival, M, Enrico Petretto, Andree Delahaye-Duriez, Danis, B, Rafal M. Kaminski, Kumar Srivastava, Prashant, Johnson, Michael R., Langley, S.R, Maxime Rotival, Johnson, M.R, Bagnati, Marta, Eyll, JV, Foerch, Patrik, Srivastava, PK, Delahaye-Duriez, A, Patrik Foerch, Jacques Behmoaras, Kaminski, R.M, Langley, SR, Johnson, MR, Behmoaras, J, Jonathan van Eyll, Petretto, E, Prashant Kumar Srivastava, Mazzuferi, M, van Eyll, Jonathan, Marta Bagnati, Kirill Shkura, Bénédicte Danis, Bagnati, M, Shkura, K, Rotival, Maxime, Petretto, Enrico, Manuela Mazzuferi   +50 more
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Maize Genome Editing and Genetic Transformation Platform

International audienceMaize genetic transformation is a critical tool for functional genomics, cellular biology, and crop improvement. It enables the study of gene function, protein localization, and supports genome editing approaches like CRISPR/Cas for
Widiez, Thomas, Rogowsky, Peter, Montes, Emilie   +2 more
core   +8 more sources

Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment

Microorganisms, 2022
Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy, Ilya Kandinov, Ekaterina Dementieva, Dmitry Gryadunov   +3 more
doaj   +1 more source

Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]

, 2007
Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core   +1 more source