Results 41 to 50 of about 473,506 (307)

The hallmarks of dietary intervention-resilient gut microbiome

npj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko, Vera E. Odintsova, Anastasia Revel-Muroz, Alexander V. Tyakht   +3 more
doaj   +1 more source

Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption

Nature Communications, 2022
CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a ...
Changchang Xin, Jianhang Yin, Shaopeng Yuan, Liqiong Ou, Mengzhu Liu, Weiwei Zhang, Jiazhi Hu   +6 more
doaj   +1 more source

"Clean" genome editing in grapevine (Vitis ssp.) [PDF]

, 2018
In recent years new plant breeding techniques (NPBT), and in particular genome editing via Crispr/Cas9, emerged as breakthrough tools for the genetic improvments of agricultural species, allowing to precisely modify specific genes in shorter time ...
Loredana Moffa, Stefano Piazza, Mickael Malnoy, Lorenza Dalla Costa   +3 more
core   +1 more source

A modular cloning toolkit for genome editing in plants [PDF]

, 2020
Background CRISPR/Cas has recently become a widely used genome editing tool in various organisms, including plants. Applying CRISPR/Cas often requires delivering multiple expression units into plant and hence there is a need for a quick and easy cloning ...
Hahn, F., Hahn, Florian, Nekrasov, V., Nekrasov, Vladimir, Korolev, Andrey, Sanjurjo Loures, Laura, Sanjurjo-Loures, L., Korolev, A.   +7 more
core   +1 more source

Large-Scale CRISPR Screen of LDLR Pathogenic Variants

Research, 2023
Familial hypercholesterolemia (FH) is a frequently occurring genetic disorder that is linked to early-onset cardiovascular disease. If left untreated, patients with this condition can develop severe cardiovascular complications.
Mengjing Li, Lerong Ma, Yiwu Chen, Jianing Li, Yanbing Wang, Wenni You, Hongming Yuan, Xiaochun Tang, Hongsheng Ouyang, Daxin Pang   +9 more
doaj   +1 more source

History of genome editing in yeast [PDF]

Yeast, 2018
AbstractFor thousands of years humans have used the budding yeast Saccharomyces cerevisiae for the production of bread and alcohol; however, in the last 30–40 years our understanding of the yeast biology has dramatically increased, enabling us to modify its genome. Although S.
Marcin G. Fraczek, Samina Naseeb, Daniela Delneri   +2 more
openaire   +3 more sources

Genome-wide analysis of differential RNA editing in epilepsy [PDF]

, 2017
The recoding of genetic information through RNA editing contributes to proteomic diversity, but the extent and significance of RNA editing in disease is poorly understood.
Michael R. Johnson, Van Eyll, J, Ko, Jeong-Hun, Shkura, Kirill, Sarah R. Langley, Kaminski, RM, KO, J-H, Mazzuferi, Manuela, Ko, J.-H, Langley, Sarah R., Foerch, P, Danis, Bénédicte, Delahaye-Duriez, Andree, Srivastava, P.K, Kaminski, Rafal M., Behmoaras, Jacques, Jeong-Hun Ko, Rotival, M, Enrico Petretto, Andree Delahaye-Duriez, Danis, B, Rafal M. Kaminski, Kumar Srivastava, Prashant, Johnson, Michael R., Langley, S.R, Maxime Rotival, Johnson, M.R, Bagnati, Marta, Eyll, JV, Foerch, Patrik, Srivastava, PK, Delahaye-Duriez, A, Patrik Foerch, Jacques Behmoaras, Kaminski, R.M, Langley, SR, Johnson, MR, Behmoaras, J, Jonathan van Eyll, Petretto, E, Prashant Kumar Srivastava, Mazzuferi, M, van Eyll, Jonathan, Marta Bagnati, Kirill Shkura, Bénédicte Danis, Bagnati, M, Shkura, K, Rotival, Maxime, Petretto, Enrico, Manuela Mazzuferi   +50 more
core   +1 more source

Towards social acceptability of genome-edited plants in industrialised countries? Emerging evidence from Europe, United States, Canada, Australia, New Zealand, and Japan [PDF]

, 2022
The agricultural biotechnology world has been divided into two blocks; countries adopting GM crops for commercial cultivation (adopters) and others without any or without relevant cultivation of such crops (non-adopters).
Yamaguchi, Tomiko, Spök, Armin, Dayé, Christian, Sprink, Thorben, Allan, Andrew C.   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Utilization of protoplasts to facilitate gene editing in plants: schemes for in vitro shoot regeneration from tissues and protoplasts of potato and rapeseed: implications of bioengineering such as gene editing of broad-leaved plants [Elektronisk resurs]

, 2022
Schemes for efficient regeneration and recovery of shoots from in vitro tissues or single cells, such as protoplasts, are only available for limited numbers of plant species and genotypes and are crucial for establishing gene editing tools on a broader ...
Kieu Phuong, Nam,, Zahid, Muhammad Awais,, Sandgrind, Sjur,, Zhu, Li-Hua,, Sveriges lantbruksuniversitet., Lenman, Marit,, Andreasson, Erik,   +6 more
core   +1 more source