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Maize Genome Editing and Genetic Transformation Platform
International audienceMaize genetic transformation is a critical tool for functional genomics, cellular biology, and crop improvement. It enables the study of gene function, protein localization, and supports genome editing approaches like CRISPR/Cas for
Widiez, Thomas +2 more
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Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
Nature Communications, 2022 Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin +15 more
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Precision genome editing [PDF]
Nature Methods, 2018 A machine learning model predicts the genotype of CRISPR–Cas9 gene editing products, thereby enabling precise, template-free correction of disease-associated mutations.
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CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells [PDF]
, 2017 The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders.
Menten, Björn +29 more
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Breakthrough to genome editing [PDF]
Science, 2015 A, T, G, C: the alphabet code for the nucleotides that are the building blocks of life. Minor, but consequential, changes in this DNA coding can change gene function. Researchers have long sought better ways to edit the genetic code in cultured cells and laboratory organisms to silence, activate, or change targeted genes to gain a better ...
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GENT2: an updated gene expression database for normal and tumor tissues
BMC Medical Genomics, 2019 Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park +3 more
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Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment
Microorganisms, 2022 Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy +3 more
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The hallmarks of dietary intervention-resilient gut microbiome
npj Biofilms and Microbiomes, 2022 Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko +3 more
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NGO perspectives on the social and ethical dimensions of plant genome-editing [PDF]
, 2019 Plant genome editing has the potential to become another chapter in the intractable debate that has dogged agricultural biotechnology. In 2016, 107 Nobel Laureates accused Greenpeace of emotional and dogmatic campaigning against agricultural ...
S Hartley (755365) +2 more
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Large-Scale CRISPR Screen of LDLR Pathogenic Variants
Research, 2023 Familial hypercholesterolemia (FH) is a frequently occurring genetic disorder that is linked to early-onset cardiovascular disease. If left untreated, patients with this condition can develop severe cardiovascular complications.
Mengjing Li +9 more
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