Results 61 to 70 of about 630,749 (290)

Exome-wide association study of bleeding events in patients receiving direct oral anticoagulants

Science Progress
Background Direct oral anticoagulants (DOACs) are first-line medications for stroke prevention in non-valvular atrial fibrillation (AF). However, variability in drug response poses risks of hemorrhagic or thromboembolic events.
Dmitry A Sychev, Anastasiia A Buianova, Sherzod P Abdullaev, Karin B Mirzaev, Vera A Belova, Anna O Shmitko, Valery V Cheranev, Oleg N Suchalko, Lyudmila V Fedina, Svetlana V Batyukina, Natalia A Shatalova, Pavel O Bochkov, Sergey V Glagolev, Denis V Rebrikov, Dmitriy O Korostin   +14 more
doaj   +1 more source

Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]

, 2018
The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan, Liu, Fenyong, Sheng, Jingxue, Trang, Phong   +3 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Gonococcal Genetic Island in the Global Neisseria gonorrhoeae Population: A Model of Genetic Diversity and Association with Resistance to Antimicrobials

Microorganisms, 2023
The aim of this work was to study the genetic diversity of the gonococcal genetic island (GGI) responsible for the type IV secretion system (T4SS) and the association of a functionally active GGI with antimicrobial resistance. An analysis of the GGI in a
Dmitry Kravtsov, Dmitry Gryadunov, Boris Shaskolskiy   +2 more
doaj   +1 more source

CRISPR-Cas9–based treatment of myocilin-associated glaucoma [PDF]

, 2018
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (MYOC) dominant gain-of-function mutations have been reported in ∼4% of POAG cases.
Bugge, Kevin, Clark, Abbot F., Fingert, John H., Jain, Ankur, Kasetti, Ramesh B., Ran, Fei, Searby, Charles C., Sharma, Tasneem P., Sheffield, Val C., Yan, Winston Xia, Zhang, Feng, Zode, Gulab   +11 more
core   +1 more source

Targeted mutagenesis using CRISPR-Cas9 in the chelicerate herbivore Tetranychus urticae [PDF]

, 2020
The use of CRISPR-Cas9 has revolutionized functional genetic work in many organisms, including more and more insect species. However, successful gene editing or genetic transformation has not yet been reported for chelicerates, the second largest group ...
Dermauw, Wannes, Jonckheere, Wim, Livadaras, Ioannis, Riga, Maria, Van Leeuwen, Thomas, Vontas, John   +5 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair

STAR Protocols, 2022
Summary: The repair products of double-stranded DNA breaks (DSBs) are crucial for investigating the mechanism underlying DNA damage repair as well as evaluating the safety and efficiency of gene-editing; however, a comprehensively quantitative assay ...
Yang Liu, Jianhang Yin, Tingting Gan, Mengzhu Liu, Changchang Xin, Weiwei Zhang, Jiazhi Hu   +6 more
doaj   +1 more source

Human Germline Genome Editing [PDF]

The American Journal of Human Genetics, 2017
With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017.
Kelly E, Ormond, Douglas P, Mortlock, Derek T, Scholes, Yvonne, Bombard, Lawrence C, Brody, W Andrew, Faucett, Nanibaa' A, Garrison, Laura, Hercher, Rosario, Isasi, Anna, Middleton, Kiran, Musunuru, Daniel, Shriner, Alice, Virani, Caroline E, Young   +13 more
openaire   +2 more sources