Results 11 to 20 of about 1,533,500 (299)
Molecular Biotechnology, 2022 Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems.
Maura McGrail +2 more
core +6 more sources
, 2018 This image is a part of the Genome Editing collection. This collection illustrates genetic mutations and using genome engineering technology to correct those mutations.https://digitalcommons.latech.edu/vista-gallery-2017/1026/thumbnail ...
FREDENS JULIUS +2 more
core +8 more sources
N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
doaj +1 more source
Genome Editing in Biotech Regulations Worldwide [PDF]
, 2023 Since the introduction of genome editing techniques in breeding and the first commercial products on the market, various governments or jurisdictions have attempted to clarify the legal classification of genome editing in relation to their genetic ...
Sprink, Thorben, Wilhelm, Ralf
core +1 more source
Genome editing to the rescue: sustainably feeding 10 billion global human population [PDF]
, 2016 Modern animal breeding strategies based on population genetics, molecular tools,artificial insemination,embryo transfer and related technologies have contributed to significant increases in the performance of domestic animals, and are the basis for a ...
Whitelaw, C. B. A. +11 more
core +3 more sources
System analysis of the sequencing quality of human whole exome samples on BGI NGS platform
Scientific Reports, 2022 Human exome sequencing is a classical method used in most medical genetic applications. The leaders in the field are the manufacturers of enrichment kits based on hybridization of cRNA or cDNA biotinylated probes specific for a genomic region of interest.
Vera Belova +10 more
doaj +1 more source
Genome editing in forest trees [PDF]
, 2023 Since the first CRISPR/Cas-mediated genome editing of poplar in 2015, an increasing number of tree species are being genome-edited. Although the availability of genome sequences, tissue culture and transformation systems are limiting factors, research is
Zahn, Virginia +3 more
core +1 more source
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities
Cell Discovery, 2023 Life science studies involving clustered regularly interspaced short palindromic repeat (CRISPR) editing generally apply the best-performing guide RNA (gRNA) for a gene of interest.
Heng Zhang +8 more
doaj +1 more source
Addressing Cognitive Vulnerabilities Through Genome and Epigenome Editing: Techno-Legal Adaptations for Persons with Intellectual Disabilities [PDF]
, 2022 Special Issue: Gene Editing, Health Innovation, Regulation.Copyright © 2022 The Author. The key aim of this paper is to highlight the oft-under-represented narrative of how persons with disabilities (specifically, those with intellectual disabilities ...
Lau, PL
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Genome Editing for Mucopolysaccharidoses [PDF]
International Journal of Molecular Sciences, 2020 Genome editing holds the promise of one-off and potentially curative therapies for many patients with genetic diseases. This is especially true for patients affected by mucopolysaccharidoses as the disease pathophysiology is amenable to correction using multiple approaches. Ex vivo and in vivo genome editing platforms have been tested primarily on MSPI
Edina Poletto +2 more
openaire +2 more sources