Results 111 to 120 of about 1,632,775 (273)
CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture.
Annual Review of Plant Biology, 2019 Enhanced agricultural production through innovative breeding technology is urgently needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas genome editing enable efficient targeted modification in most crops, thus promising
Kunling Chen +4 more
semanticscholar +1 more source
Pairwise sequence alignment with block and character edit operations [PDF]
arXiv, 2023 Pairwise sequence comparison is one of the most fundamental problems in string processing. The most common metric to quantify the similarity between sequences S and T is edit distance, d(S,T), which corresponds to the number of characters that need to be substituted, deleted from, or inserted into S to generate T.
arxiv
LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis
Cells, 2022 TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC.
Violetta S. Gogoleva +5 more
doaj +1 more source
mBio, 2022 Previous studies suggest that short peptides from the heptad repeat 2 (HR2) domain of gp41 expressed on the cell surface are more potent inhibitors of HIV-1 entry than soluble analogs.
Alexandra Maslennikova +9 more
doaj +1 more source
Advances in Engineering the Fly Genome with the CRISPR-Cas System. [PDF]
, 2018 Drosophila has long been a premier model for the development and application of cutting-edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the genome with ease and precision, providing a rich toolbox to interrogate ...
Bier, Ethan +3 more
core +2 more sources
Circular RNA-mediated inverse prime editing in human cells
Nature CommunicationsPrime editors are restricted to performing precise edits downstream of cleavage sites, thereby limiting their editing scope. Therefore, we develop inverse prime editors (iPEs) that act upstream of the nickase cleavage site by replacing nCas9-H840A with ...
Ronghong Liang +9 more
doaj +1 more source
Scientific Reports, 2022 Endogenous retroviruses (ERVs) are retroviral sequences present in the host genomes. Although most ERVs are inactivated, some are produced as replication-competent viruses from host cells.
Sayumi Shimode +3 more
doaj +1 more source
Genome editing: the end of the beginning [PDF]
Genome Biology, 2015 Editorial It has recently become commonplace to editorialize on the extent to which genome editing has transformed modern biological research and perhaps, in the future, biomedicine. Nonetheless, each time the scope of scientific progress and the state of the field is appraised, it is followed in rapid succession by another wave of seemingly momentous ...
Doudna, Jennifer A, Gersbach, Charles A
openaire +5 more sources
Scaffolder - Software for Reproducible Genome Scaffolding. [PDF]
, 2011 Background: Assembly of short-read sequencing data can result in a fragmented non-contiguous series of genomic sequences. Therefore a common step in a genome project is to join neighboring sequence regions together and fill gaps in the assembly using ...
Hazel A. Barton, Michael D. Barton
core +1 more source
Learning Genomic Sequence Representations using Graph Neural Networks over De Bruijn Graphs [PDF]
arXiv, 2023 The rapid expansion of genomic sequence data calls for new methods to achieve robust sequence representations. Existing techniques often neglect intricate structural details, emphasizing mainly contextual information. To address this, we developed k-mer embeddings that merge contextual and structural string information by enhancing De Bruijn graphs ...
arxiv