Results 131 to 140 of about 571,422 (359)

The commercialization of genome-editing technologies

Critical Reviews in Biotechnology, 2017
The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational ...
Emily Vallillo, Seok Hyun Yun, Katelyn N. Brinegar, Ali Khademhosseini, Ali K. Yetisen, Sun Choi, Guillermo U. Ruiz-Esparza, Anand M. Prabhakar   +7 more
openaire   +2 more sources

Heterozygous deletion of 10q24.31-q24.33– a new syndrome associated with multiple congenital anomalies: case report and literature review

Neurological Research and Practice
Background Congenital anomalies and neurodevelopmental disorders are complex conditions often requiring comprehensive diagnostic approaches. Next-generation sequencing (NGS), particularly whole-exome sequencing (WES), has greatly improved the detection ...
Anastasiia A. Buianova, Yulia S. Lashkova, Tatiana V. Kulichenko, Ivan S. Kuznetsov, Artem A. Ivanov, Olga P. Parshina, Oleg N. Suchalko, Svetlana S. Vakhlyarskaya, Dmitriy O. Korostin   +8 more
doaj   +1 more source

Simultaneous precise editing of multiple genes in human cells

, 2019
. When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results ...
Chintalapati, M., Kanis, P., Macak, D., Maricic, T., Pääbo, S., Riesenberg, S.   +5 more
core   +1 more source

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases [PDF]

, 2008
Elena Pérez, Jianbin Wang, Jeffrey C. Miller, Yann Jouvenot, Kenneth A Kim, Olga Liu, Nathaniel Wang, Gary Lee, Victor V. Bartsevich, Ya-Li Lee, Dmitry Guschin, Igor Rupniewski, Adam James Waite, Carmine Carpenito, Richard G. Carroll, Jordan S. Orange, Fyodor D. Urnov, Edward J. Rebar, Dale Ando, Philip D. Gregory, James L. Riley, Michael C. Holmes, Carl H. June   +22 more
openalex   +1 more source

A Review On Genome Editing

, 2017
The Present Review report contains the information about Genome Editing. In this report genome editing is illustrated at the basic level for better understanding. It contains History of Genome Editing from 1800 to Current day i.e. from concept of DNA till current time.
H. P. Suryawanshi, Akshay Patil, Latesh Patil, Samadhan P. Pawar   +3 more
openaire   +2 more sources

Characterization of the thermophilic xylanase Fsa02490Xyn from the hyperthermophile Fervidibacter sacchari belonging to glycoside hydrolase family 10

FEBS Open Bio, EarlyView.
Fervidibacter sacchari is a member of the bacterial phylum Armatimonadota, only a few of which have been cultivated. It is a hyperthermophilic polysaccharide degradation specialist. We show that a secreted enzyme, Fsa02490Xyn, is an endoxylanase belonging to glycoside hydrolase family 10.
Nicole Torosian, Jonathan K. Covington, Allison M. Cook, Nancy O. Nou, Marike Palmer, Ritesh Mewalal, Miranda Harmon‐Smith, Ian K. Blaby, Jan‐Fang Cheng, Matthias Hess, Brian P. Hedlund   +10 more
wiley   +1 more source

p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3

Cell Communication and Signaling
Sestrin1 and Sestrin2 (SESN1&2) are evolutionarily conserved, stress-responsive proteins that regulate cell growth and viability. The primary target of Sestrins is the mTORC1 protein kinase, an activator of anabolic processes and an autophagy inhibitor ...
Alexander Haidurov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, George S. Krasnov, Anna V. Kudryavtseva, Andrei V. Budanov   +5 more
doaj   +1 more source

Scaffolder - Software for Reproducible Genome Scaffolding. [PDF]

, 2011
Background: Assembly of short-read sequencing data can result in a fragmented non-contiguous series of genomic sequences. Therefore a common step in a genome project is to join neighboring sequence regions together and fill gaps in the assembly using ...
Hazel A. Barton, Michael D. Barton
core   +1 more source

Bio-Communication of Bacteria and its Evolutionary Interrelations to Natural Genome Editing Competences of Viruses [PDF]

, 2008
Guenther Witzany
openalex   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source