Results 141 to 150 of about 1,632,775 (273)

Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy

Genome Medicine
Background Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in treating hematologic malignancies. However, its efficacy against solid tumors remains limited. One of the major challenges is the lack of specific tumor antigens.
Xiaohong Liu, Yue Sun, Boxu Lin, Hao Xiong, Xinyue Lu, Binghe Tan, Chenglin Zhang, Mingyao Liu, Juliang Qin, Na Zhang, Bing Du   +10 more
doaj   +1 more source

Investigation of Gene Expression and DNA Methylation From Seven Different Brain Regions of a Crab-Eating Monkey as Determined by RNA-Seq and Whole-Genome Bisulfite Sequencing

Frontiers in Genetics, 2019
The crab-eating monkey is widely used in biomedical research for pharmacological experiments. Epigenetic regulation in the brain regions of primates involves complex patterns of DNA methylation.
Won-Jun Lim, Won-Jun Lim, Kyoung Hyoun Kim, Kyoung Hyoun Kim, Jae-Yoon Kim, Jae-Yoon Kim, Hee-Jin Kim, Mirang Kim, Jong-Lyul Park, Seokjoo Yoon, Jung-Hwa Oh, Jae-Woo Cho, Yong Sung Kim, Namshin Kim, Namshin Kim   +14 more
doaj   +1 more source

Genome Analysis-Strategies for Physical Mapping. Vol. 4. Edited by Kay E. Davies and Shirley M. Tilghman. Cold Spring Harbor Laboratory Press. 1992. 165 pages. Price $49. ISBN 0 87969 412 2. [PDF]

, 1993
Veronica van Heyningen
openalex   +1 more source

Regional Physical Mapping: Genome Analysis, vol. 5. Edited by K. E. Davies, and S. M. Tilghman. Cold Spring Harbor Laboratory Press. 1993. 140 pages. Cloth. $49.00. ISBN 0 87969 413 0. [PDF]

, 1994
Wendy A. Bickmore
openalex   +1 more source

Broad-spectrum resistance to bacterial blight in rice using genome editing

Nature Biotechnology, 2019
Bacterial blight of rice is an important disease in Asia and Africa. The pathogen, Xanthomonas oryzae pv. oryzae (Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at ...
R. Oliva, Chonghui Ji, Genelou Atienza-Grande, J. Huguet-Tapia, Alvaro L Perez Quintero, Tingyu Li, J. Eom, Chenhao Li, Hanna Nguyen, Bo Liu, F. Auguy, Coline Sciallano, V. Luu, G. S. Dossa, S. Cunnac, S. M. Schmidt, I. Slamet-Loedin, C. Vera Cruz, B. Szurek, W. Frommer, F. White, Bing Yang   +21 more
semanticscholar   +1 more source

The Mitochondrial Genome of Cathaya argyrophylla Reaches 18.99 Mb: Analysis of Super-Large Mitochondrial Genomes in Pinaceae [PDF]

arXiv
Mitochondrial genomes in the Pinaceae family are notable for their large size and structural complexity. In this study, we sequenced and analyzed the mitochondrial genome of Cathaya argyrophylla, an endangered and endemic Pinaceae species, uncovering a genome size of 18.99 Mb, meaning the largest mitochondrial genome reported to date.
arxiv  

Perfectly matched 20-nucleotide guide RNA sequences enable robust genome editing using high-fidelity SpCas9 nucleases

Genome Biology, 2017
High-fidelity SpCas9 variants (eSpCas9 and SpCas9-HF1) have been engineered to reduce off-target effects. We found that changes in guide RNA length induced significant reductions in the editing activities of SpCas9 variants in plant cells.
Dingbo Zhang, Huawei Zhang, Tingdong Li, Kunling Chen, Jin-Long Qiu, Caixia Gao   +5 more
doaj   +1 more source

Agptools: a utility suite for editing genome assemblies [PDF]

arXiv
The AGP format is a tab-separated table format describing how components of a genome assembly fit together. A standard submission format for genome assemblies is a fasta file giving the sequence of contigs along with an AGP file showing how these components are assembled into larger pieces like scaffolds or chromosomes.
arxiv  

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

Genome Biology
CRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand the effect of genetic perturbations including single nucleotide variants (SNVs) associated with diseases.
Sarah E. Cooper, Matthew A. Coelho, Magdalena E. Strauss, Aleksander M. Gontarczyk, Qianxin Wu, Mathew J. Garnett, John C. Marioni, Andrew R. Bassett   +7 more
doaj   +1 more source