Results 191 to 200 of about 571,422 (359)

The Mutations and Their Relationships with the Genome and Epigenome, RNAs Editing and Evolution in Eukaryotes

, 2012
Daniel Frías-Lasserre
openalex   +2 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Human genome editing as a tool to establish causality [PDF]

, 2014
Fyodor D. Urnov
openalex   +1 more source

Fluid Shear‐Controlled Pro/Anti‐Inflammatory Osteomodulatory Construct for Drug‐Free Immune Activation Through Cationic Ion Channel Activation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed PCL scaffold coated with Arginine was laminated with electrospun polyvinyl alcohol (PVA) nanofibers containing cationic cellulose nanocrystals (PVA@cCNC). This created nanoisland‐like regions of aligned and random cCNC‐rich fibers. The composite scaffold, under fluid shear stimulation, modulated macrophage polarization from M1 to M2 ...
Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim   +8 more
wiley   +1 more source

Emerging trends in prime editing for precision genome editing. [PDF]

Exp Mol Med
Lee J, Kweon J, Kim Y.
europepmc   +1 more source

Faculty Opinions recommendation of In vivo genome editing using a high-efficiency TALEN system.

, 2012
Avinash Bhandoola
openalex   +1 more source

Genome editing of BmFib-H gene provides an empty Bombyx mori silk gland for a highly efficient bioreactor [PDF]

, 2014
Sanyuan Ma, Run Shi, Xiaogang Wang, Yuanyuan Liu, Jiasong Chang, Jie Gao, Wei Lü, Jianduo Zhang, Ping Zhao, Qingyou Xia   +9 more
openalex   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Directed evolution expands CRISPR-Cas12a genome-editing capacity. [PDF]

Nucleic Acids Res
Ma E, Chen K, Shi H, Wasko KM, Esain-Garcia I, Trinidad MI, Zhou K, Ye J, Doudna JA.   +8 more
europepmc   +1 more source

Faculty Opinions recommendation of FLASH assembly of TALENs for high-throughput genome editing.

, 2012
Carlos F. Barbas, Charles A. Gersbach
openalex   +2 more sources