Results 191 to 200 of about 622,112 (341)

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

Editorial: CRISPR-Based Genome Editing in Translational Research-2nd Edition. [PDF]

Cells
Xu J, Zhang J, Yang D.
europepmc   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

How to talk about genome editing [PDF]

, 2018
Sandy Starr
openalex   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR-Cas9-based genome editing. [PDF]

mLife
Chen Q, Yao J, Lu Y, Qiu R, Deng Z, Sun Y.   +5 more
europepmc   +1 more source

CRISPR-Cas9 Mediated Gene Editing: A Revolution in Genome Engineering [PDF]

, 2017
Shilpa Sampathi, P Horvath, R Barrangou, J Garneau, M Dupuis, M Villion, D Romero, R Barrangou, Le Cong, F, Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, W Jiang, D Bikard, D Cox, F Zhang, L Marraffini, H Yang, H Wang, C Shivalila, A Cheng, L Shi, J Sander, J Joung, P Mali, K Esvelt, G Church, P Hsu, D Scott, J Weinstein, F Ran, S Konermann, F Ran, P Hsu, C Lin, J Gootenberg, S Konermann, J Kim, D Kim, S Kim, J Kim, I Lokody, Vikram Pattanayak, Steven Lin, John Guilinger, Enbo Ma, Jennifer Doudna, Abba Malina, John Mills, Regina Cencic, Yifei Yan, James Fraser, A Xiao, Z Wang, Y Hu, Y Wu, Z Luo, G Amitai, R Sorek, M Bolukbasi, A Gupta, S Wolfe, T Auer, K Duroure, A De Cian, J Concordet, Del Bene, F, R Deans, D Morgens, A kesli, S Pillay, M Horlbeck, D Du, L Qi, Y Guo, Q Xu, D Canzio, J Shou, J Li   +81 more
openalex   +1 more source

Genome editing [PDF]

Nature, 2015
openaire   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Nanomaterials in gene therapy and genome editing: challenges and emerging directions. [PDF]

J Nanobiotechnology
Jiang M, Zhang K, Wang Z, Gao M, Su S, He J, Xu H, Bo Z, Jiang Z, Zhang C, Hui JH, Wei R.   +11 more
europepmc   +1 more source