Results 201 to 210 of about 429,102 (229)

Engineering the hypercompact miniature IscB-ωRNA systems for efficient rice genome editing. [PDF]

Plant Commun
Li Y, Li C, Yang J, Sun X, Li J, Yan L, Zhang C, Li S, He Y, Xia L.   +9 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Engineering the MmeFz2-ωRNA system for efficient genome editing through an integrated computational-experimental framework. [PDF]

Nat Commun
Li S, Xu K, Li G, Jiang H, Wu Z, Gao P, Yue Y, Chen Y, Liu Z, Zhou B, Zhou M, Chen Y, Liu X, Wang X, Wu Z, Wei Y.   +15 more
europepmc   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

Molecular Regulators of In Vitro Regeneration in Wheat: Roles of Morphogenic Factors in Transformation, Genome Editing, and Breeding. [PDF]

Int J Mol Sci
Kowalik S, Samoń M, Przyborowski M.
europepmc   +1 more source

Public opinion survey on heritable human genome editing in South Africa: a study protocol. [PDF]

Glob Health Action
Pillay S, Thaldar D.
europepmc   +1 more source

An engineered CRISPR-Cas12i tool for efficient multiplexed genome editing. [PDF]

Nucleic Acids Res
Wang L, Wang Y, Chen J, Zhu Y, Qin H, Liu J, Ai Y, Lai J, Lian Z, Han H.   +9 more
europepmc   +1 more source

Correction: Efficient genome editing in Pseudomonas syringae pv. actinidiae using the CRISPR/FnCas12a system. [PDF]

Mol Hortic
Gou Z, Wang Y, Qin C, Yan F, Du X, Xu Z, Zhu B, Liu P, Zhou H, Chen G.   +9 more
europepmc   +1 more source

Optimization of CRISPR/Cas12 tools for plant genome editing. [PDF]

Plant Physiol
Selma S.
europepmc   +1 more source

Transgene-free genome editing in citrus and poplar meristem tissues via biolistic ribonucleoprotein delivery of CRISPR-Cas9. [PDF]

Plant Cell Rep
Rocha DC, Omoregbee MO, Luo W, Fang H, Ye Q, Liu Y, Li G, Mascoveto J, de Souza AA, Coleman G, Culver JN, Qi Y.   +11 more
europepmc   +1 more source