Results 201 to 210 of about 1,963,187 (422)

Letter from the editor: adenosine‐to‐inosine RNA editing in Alu repeats in the human genome [PDF]

, 2005
Keren Levanon, Eli Eisenberg, Gideon Rechavi, Erez Y. Levanon   +3 more
openalex   +1 more source

Genome editing is revolutionizing biology [PDF]

Cell & Bioscience, 2017
https://doi.org/10.1186/s13578-017-0162 ...
openaire   +5 more sources

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Identifying key developments, issues and questions relating to techniques of genome editing with engineered nucleases. [PDF]

, 2015
This paper discusses scientific, ethical and governance aspects of genome editing with engineered nucleases. First, the scientific state of the art for three major genome editing techniques and their current applications in humans, animals and plants are
Newson, A.J., Wrigley, A
core   +2 more sources

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T Cells

Biomedicines
T lymphocytes represent a promising target for genome editing. They are primarily modified to recognize and kill tumor cells or to withstand HIV infection. In most studies, T cell genome editing is performed using the CRISPR/Cas technology. Although this
Natalia Kruglova, Mikhail Shepelev
doaj   +1 more source

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases [PDF]

, 2008
Elena Pérez, Jianbin Wang, Jeffrey C. Miller, Yann Jouvenot, Kenneth A Kim, Olga Liu, Nathaniel Wang, Gary Lee, Victor V. Bartsevich, Ya-Li Lee, Dmitry Guschin, Igor Rupniewski, Adam James Waite, Carmine Carpenito, Richard G. Carroll, Jordan S. Orange, Fyodor D. Urnov, Edward J. Rebar, Dale Ando, Philip D. Gregory, James L. Riley, Michael C. Holmes, Carl H. June   +22 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Curated loci prime editing (cliPE) for accessible multiplexed assays of variant effect (MAVEs) [PDF]

arXiv
Multiplexed assays of variant effect (MAVEs) perform simultaneous characterization of many variants. Prime editing has been recently adopted for introducing many variants in their native genomic contexts. However, robust protocols and standards are limited, preventing widespread uptake. Herein, we describe curated loci prime editing (cliPE) which is an
arxiv  

Bio-Communication of Bacteria and its Evolutionary Interrelations to Natural Genome Editing Competences of Viruses [PDF]

, 2008
Guenther Witzany
openalex   +1 more source

A Review On Genome Editing

, 2017
The Present Review report contains the information about Genome Editing. In this report genome editing is illustrated at the basic level for better understanding. It contains History of Genome Editing from 1800 to Current day i.e. from concept of DNA till current time.
H. P. Suryawanshi, Akshay Patil, Latesh Patil, Samadhan P. Pawar   +3 more
openaire   +2 more sources