Results 231 to 240 of about 630,749 (290)

Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing. [PDF]

Sci Adv
Song LCT, Alker ATP, Oromí-Bosch A, Swartz SE, Martinson JNV, Arora J, Wang AM, Rovinsky R, Smith SJ, Pierce EC, Deutschbauer AM, Doudna JA, Cress BF, Rubin BE.   +13 more
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Editorial: Engineering future crops through genome editing. [PDF]

Front Plant Sci
Tuncel A, Kim HU, Kim MC.
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

From Bench to Bedside: Ethical and Clinical Best Practices for Genome Editing Applications. [PDF]

Int J Mol Sci
Ortiz-Bueno M, Zinghirino F, Serra PP, Paschoudi K, Montoliu L, Atilla E, Luo Y, Cavazza A, Lederer CW, Benabdellah K.   +9 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Advances in the use of morphogenic regulators and peptide regenerating factors for boosting plant transformation and genome editing. [PDF]

Front Plant Sci
Achary VMM, Syombua ED, Kaur S, Katamreddy SC, Zou D, Hearne SJ, Bandyopadhyay A.   +6 more
europepmc   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

High-efficiency, transgene-free plant genome editing by viral delivery of an engineered TnpB. [PDF]

Nat Plants
Nagalakshmi U, Rodriguez JE, Nguyen T, Weissman RF, Thornton BW, Terrace CI, Savage DF, Dinesh-Kumar SP.   +7 more
europepmc   +1 more source