Results 231 to 240 of about 1,457,553 (300)

AI-Guided DNA-Free and Genotype-Independent Genome Editing for Soybean Improvement. [PDF]

Plants (Basel)
Kim HJ, Chae J, Han SJ, Kim JH, Chung YS, Karthik S, Heo JB.   +6 more
europepmc   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Vascular-specific genome editing enhances low-phosphate tolerance in rice. [PDF]

Plant Cell
Chia JC.
europepmc   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

Efficient genome editing with chimeric oligonucleotide-directed editing. [PDF]

Nat Commun
Nguyen LT, Rakestraw NR, Pizzano BLM, Iyyappan R, Young CB, Huang Y, Beerensson KT, Fang A, Antal SG, Anamisis KV, Peggs CMD, Yan J, Jing Y, Lewis JG, Burdine RD, Adamson B, Jiang Z, Toettcher JE, Myhrvold C, Jain PK.   +19 more
europepmc   +1 more source

Visible‐Blind Near‐Infrared Organic Vision Sensors for Imaging in Adverse Environmental Conditions

Advanced Optical Materials, EarlyView.
This work presents high‐performance visible‐blind NIR OPDs enabled by a multilayer optical modulation layer. The devices achieve strong visible‐light suppression and enhanced NIR sensitivity, enabling robust imaging in foggy or low‐light environments.
Baozhong Deng, Kean Lu, Zhouyi Lu, Yi Li, Gaoyu Dai, Luqiao Yin, Zihan Wang, Bruno Grandidier, Tao Xu, Furong Zhu   +9 more
wiley   +1 more source

Optimization of genome editing strategies for targeted integration at chicken sex chromosome loci. [PDF]

Poult Sci
Cao Z, Chen C, He Y, Wei W, Song J, Han W, Xue Q, Chen G, Li B, Jin K.   +9 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Inducible CRISPRi enables efficient and high-fidelity genome editing in Streptomyces. [PDF]

Nucleic Acids Res
Bai C, Zhu H, Bayona LM, Du C, van Wezel GP.   +4 more
europepmc   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source