Results 241 to 250 of about 1,457,553 (300)

A PepFect14 analog improves non-viral CRISPR delivery in primary human cells to facilitate genome editing and repair. [PDF]

Bioeng Transl Med
du Rand A, Masterson C, Verdon D, Siow A, Loef E, Dunbar R, Kingston R, Harris P, Sheppard H.   +8 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Improving iSpyMacCas9 multiplex genome editing in rice by CRISPR-combo-mediated BBM1 activation. [PDF]

Plant J
Byiringiro I, Contiliani DF, Davies C, Gurel F, Creste S, Qi Y.   +5 more
europepmc   +1 more source

Powering Genome Editing in Rice by Harnessing Promising Gene Resources: A Comprehensive Roadmap. [PDF]

Physiol Plant
Solanki M, Yousuf F, Srivastava A, Vaikuntapu PR, Molla K, Neeraja CN, Thakur V, Barbadikar KM, Sundaram RM, Mohannath G, Mangrauthia SK.   +10 more
europepmc   +1 more source

Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy. [PDF]

Front Med (Lausanne)
Hu B, Gutty VSR, Herzog RW, Duan D.
europepmc   +1 more source

Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency. [PDF]

Nat Commun
Saxena S, Kabra M, Abdeen AA, Tabima DM, Sinha D, Rawding PA, Zhu M, Xie R, Kulkarni T, Hanstad GM, Fernandez Zepeda MA, Gamm DM, Pattnaik BR, Gong S, Saha K.   +14 more
europepmc   +1 more source

Monitoring biological effects of somatic cell genome editing. [PDF]

Nat Rev Genet
Freedman BS, Bulte JWM, Conklin BR, Judge LM, Dwinell MR, Geurts AM, Sitton MJ, Mahajan V, Kiani S, Gersbach CA, Ebrahimkhani MR, Kelly JJ, Ronald JA, Morizane R, Gupta N, Shakeri-Zadeh A, Vo N, Saha K, Saxena S, Gamm DM, Sinha D, Tarantal AF, Vandsburger M, Matsubara A, Fu H, Tsai SQ, SCGE Dissemination and Coordinating Center Toolkit Team, SCGE Biological Effects Initiative.   +27 more
europepmc   +1 more source

The genome editing revolution

Trends in Biotechnology, 2023
A series of spectacular scientific discoveries and technological advances in the second half of the 20th century have provided the basis for the ongoing genome editing revolution. The elucidation of structural and functional features of DNA and RNA was followed by pioneering studies on genome editing: Molecular biotechnology was born.
John van der Oost, Constantinos Patinios   +1 more
exaly   +3 more sources

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Foetal genome editing

Current Opinion in Obstetrics & Gynecology, 2023
Purpose of review The development of modern gene editing tools alongside promising innovations in gene sequencing and prenatal diagnostics as well as a shifting regulatory climate around targeted therapeutics offer an opportunity to address monogenic diseases prior to the onset of pathology. In this review, we seek to highlight
Sourav K, Bose, Kara, Kennedy, William H, Peranteau   +2 more
openaire   +2 more sources

Genome Editing and Obesity

2022
Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant number of diseases. The incidence of obesity does not solely depend on dietary habits, with energy balance being regulated by the complex interactions between genetic, behavioural and environmental factors ...
Masi D., Tozzi R., Watanabe M.
openaire   +3 more sources