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CGIAR Project on Genome Editing: Annual Technical Report 2024
CGIAR Research Initiative on Genome Editing
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Current Opinion in Obstetrics & Gynecology, 2023
Purpose of review The development of modern gene editing tools alongside promising innovations in gene sequencing and prenatal diagnostics as well as a shifting regulatory climate around targeted therapeutics offer an opportunity to address monogenic diseases prior to the onset of pathology. In this review, we seek to highlight
Sourav K, Bose +2 more
openaire +2 more sources
Purpose of review The development of modern gene editing tools alongside promising innovations in gene sequencing and prenatal diagnostics as well as a shifting regulatory climate around targeted therapeutics offer an opportunity to address monogenic diseases prior to the onset of pathology. In this review, we seek to highlight
Sourav K, Bose +2 more
openaire +2 more sources
2022
Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant number of diseases. The incidence of obesity does not solely depend on dietary habits, with energy balance being regulated by the complex interactions between genetic, behavioural and environmental factors ...
Masi D., Tozzi R., Watanabe M.
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Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant number of diseases. The incidence of obesity does not solely depend on dietary habits, with energy balance being regulated by the complex interactions between genetic, behavioural and environmental factors ...
Masi D., Tozzi R., Watanabe M.
openaire +3 more sources
2023
Silkworm is a lepidopteran insect that has been used as a model for a wide variety of biological studies. The microinjection technique is available, and it is possible to cause transgenesis as well as target gene disruption via the genome editing technique. TALEN-mediated knockout is especially effective in this species.
Takuya, Tsubota +2 more
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Silkworm is a lepidopteran insect that has been used as a model for a wide variety of biological studies. The microinjection technique is available, and it is possible to cause transgenesis as well as target gene disruption via the genome editing technique. TALEN-mediated knockout is especially effective in this species.
Takuya, Tsubota +2 more
openaire +2 more sources
2021
Genome editing has perhaps become the most popular toolbox for generating targeted mutations. Over 0.3% of all publications in PubMed are currently concerned with this topic, demonstrating its importance. Since 2012, there has been an exponential explosion in research articles, owing primarily due to the clustered regulatory interspaced short ...
Henrik U. Stotz, Nobuya Koizuka
+6 more sources
Genome editing has perhaps become the most popular toolbox for generating targeted mutations. Over 0.3% of all publications in PubMed are currently concerned with this topic, demonstrating its importance. Since 2012, there has been an exponential explosion in research articles, owing primarily due to the clustered regulatory interspaced short ...
Henrik U. Stotz, Nobuya Koizuka
+6 more sources
Genome editing with retroelements
Science, 2023RNA-guided DNA writing enzymes offer promise for programmable gene ...
Stephen, Tang, Samuel H, Sternberg
openaire +2 more sources
2017
Gene-modified monkey models would be particularly valuable in biomedical and neuroscience research. Virus-based transgenic and programmable nucleases-based site-specific gene editing methods (TALEN, CRISPR-cas9) enable the generation of gene-modified monkeys with gain or loss of function of specific genes. Here, we describe the generation of transgenic
Zhen, Liu, Yijun, Cai, Qiang, Sun
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Gene-modified monkey models would be particularly valuable in biomedical and neuroscience research. Virus-based transgenic and programmable nucleases-based site-specific gene editing methods (TALEN, CRISPR-cas9) enable the generation of gene-modified monkeys with gain or loss of function of specific genes. Here, we describe the generation of transgenic
Zhen, Liu, Yijun, Cai, Qiang, Sun
openaire +2 more sources
2023
Medaka (Oryzias latipes), along with zebrafish (Danio rerio), is a useful experimental model fish. Here, we describe a simple method for generating medaka gene knockout strains using an automated microchip electrophoresis system. We also describe a method for targeted gene knockin using a plasmid carrying a sequence that does not cause off-target ...
Rie, Hara +2 more
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Medaka (Oryzias latipes), along with zebrafish (Danio rerio), is a useful experimental model fish. Here, we describe a simple method for generating medaka gene knockout strains using an automated microchip electrophoresis system. We also describe a method for targeted gene knockin using a plasmid carrying a sequence that does not cause off-target ...
Rie, Hara +2 more
openaire +2 more sources
2022
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
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The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
openaire +2 more sources