Results 271 to 280 of about 1,963,187 (422)

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

An efficient mRNA delivery system for genome editing in plants. [PDF]

Plant Biotechnol J
Qiu F, Xue C, Liu J, Li B, Gao Q, Liang R, Chen K, Gao C.   +7 more
europepmc   +1 more source

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells [PDF]

, 2015
Ayal Hendel, Rasmus O. Bak, Joseph T. Clark, Andrew Kennedy, Daniel E. Ryan, Subhadeep Roy, Israel Steinfeld, Benjamin D. Lunstad, Robert Kaiser, Alec B. Wilkens, Rosa Bacchetta, Anya Tsalenko, Douglas J. Dellinger, Laurakay Bruhn, Matthew H. Porteus   +14 more
openalex   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Genome Editing in Mouse Embryo Using the CRISPR/Cas12i3 System. [PDF]

Int J Mol Sci
He J, Liu J, Yue Y, Wang L, Liu Z, Xi G, An L, Tian J, Wang Y.   +8 more
europepmc   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

CRISPR-Cas12i confers efficient genome editing and gene regulation in plants. [PDF]

Plant Physiol
He Y, Liao S, Ren Q, Tang X, Zheng X, Qi Y, Zhang Y.   +6 more
europepmc   +1 more source

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

Cell, 2020
Dan Wang, Feng Zhang, G. Gao
semanticscholar   +1 more source

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

Advanced Science, EarlyView.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang, Yunxing Huang, Yin Tong, Kenneth Tsz Chun Ng, Jiangwen Zhang   +4 more
wiley   +1 more source

In planta genome editing in citrus facilitated by co-expression of CRISPR/Cas and developmental regulators. [PDF]

Plant J
Kelly G, Plesser E, Bdolach E, Arroyave M, Belausov E, Doron-Faigenboim A, Rozen A, Zemach H, Zach YY, Goldenberg L, Arad T, Yaniv Y, Sade N, Sherman A, Eyal Y, Carmi N.   +15 more
europepmc   +1 more source