Results 291 to 300 of about 1,963,187 (422)

Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases

, 2014
Yujia Cai, Rasmus O. Bak, Jacob Giehm Mikkelsen   +2 more
openalex   +1 more source

Engineered Viruses as Genome Editing Devices [PDF]

, 2015
Xiaoyu Chen, Manuel A. F. V. Gonçalves
openalex   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

Genome editing, an opportunity to revive soybean cultivation in Europe. [PDF]

Plant J
Monfort M, Buitink J, Roeber F, Nogué F.   +3 more
europepmc   +1 more source

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury

Advanced Science, EarlyView.
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang   +12 more
wiley   +1 more source

Protocol for the functional evaluation of genetic variants using saturation genome editing. [PDF]

STAR Protoc
Obolenski S, Olvera-León R, Sun D, Adams DJ, Waters AJ.   +4 more
europepmc   +1 more source

Bacterial Delivery of TALEN Proteins for Human Genome Editing

, 2014
Jingyue Jia, Yongxin Jin, Ting Bian, Donghai Wu, Lijun Yang, Naohiro Terada, Weihui Wu, Shouguang Jin   +7 more
openalex   +2 more sources

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

Advanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang, Mingda Wang, Nanya Wang, Mingxin Pan, Yu Xu, Qiancheng You, Lanqing Yao, Jiahao Xu, Lihui Gu, Xiaodong Sun, Lei Zhang, Jiayue Xu, Bingsi Li, Guoqiang Wang, Shangli Cai, Guoyue Lv, Feng Shen   +16 more
wiley   +1 more source

A CRISPR-SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus. [PDF]

Nucleic Acids Res
Sun J, Yu X, Tang G, Chen M, Zheng Y, Hu Y, Li Q, Li X, Li N, Li Z, Li Y, Lu N, Tan W, Yang Y, Lyu X, Zhao G, Wang H, Dai L, Zhao GP, Ai L, Zhao W.   +20 more
europepmc   +1 more source

54. Genome Editing of Primary Human CD34+ Hematopoietic Stem Cells Enables a Safe Harbor Targeted Gene Addition Therapeutic Strategy for Chronic Granulomatous Disease [PDF]

, 2015
Suk See De Ravin, Andreas Reik, Peiqi Liu, Linhong Li, Madhusudan V. Peshwa, Narda Theobald, Uimook Choi, Janet Lee, Sherry Koontz, Gary Lee, Philip D. Gregory, Fyodor D. Urnov, Harry L. Malech   +12 more
openalex   +1 more source