Results 11 to 20 of about 874,950 (354)
Measuring genome evolution [PDF]
Proceedings of the National Academy of Sciences, 1998 The determination of complete genome sequences provides us with an opportunity to describe and analyze evolution at the comprehensive level of genomes. Here we compare nine genomes with respect to their protein coding genes at two levels: ( i ) we compare genomes as “bags of genes” and measure the fraction of ...
M A, Huynen, P, Bork
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Current Issues in Molecular Biology, 2003 Genomics today involves the study of many genes at a time in order to gain an integrated picture of the cell or organism as a whole. This review considers the architecture and evolution of bacterial genomes. The many facets of large-scale functional investigation in a variety of bacteria and the search to find common rules in their dynamic and ...
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Genomic, Network, and Phylogenetic Analysis of the Oomycete Effector Arsenal
mSphere, 2017 The oomycetes are a class of microscopic, filamentous eukaryotes within the stramenopiles-alveolate-Rhizaria (SAR) supergroup and include ecologically significant animal and plant pathogens.
Jamie McGowan, David A. Fitzpatrick
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Habitats Within the Plant Root Differ in Bacterial Network Topology and Taxonomic Assortativity
Molecular Plant-Microbe Interactions, 2023 The root microbiome is composed of distinct epiphytic (rhizosphere) and endophytic (endosphere) habitats. Differences in abiotic and biotic factors drive differences in microbial community diversity and composition between these habitats, though how they
Connor R. Fitzpatrick +5 more
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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David +7 more
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Frontiers in Bioengineering and Biotechnology, 2022 Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models can generate drug response specific to patients, they are not sustainable in ...
Louis Jun Ye Ong +22 more
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Time series model based on global structure of complete genome [PDF]
, 2000 A time series model based on the global structure of the complete genome is proposed. Three kinds of length sequences of the complete genome are considered. The correlation dimensions and Hurst exponents of the length sequences are calculated.
Allegrini +22 more
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Expansion of CORE-SINEs in the genome of the Tasmanian devil [PDF]
, 2012 Background: The genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that ...
Hallström, Björn M. +4 more
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Nature Reviews Drug Discovery, 2004 As a result of the need to transform into drug discovery companies, genomics companies have had to change their recruitment models.
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SequelTools: a suite of tools for working with PacBio Sequel raw sequence data
BMC Bioinformatics, 2020 Background PacBio sequencing is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodology.
David E. Hufnagel +2 more
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