Results 41 to 50 of about 3,706,718 (308)

Evolution of a hot genome [PDF]

Proceedings of the National Academy of Sciences, 2014
The chile pepper has a long and important human history. Chiles, members of the plant genus Capsicum in the Solanaceae family, evolved in the New World and were domesticated there several millennia ago (1). Although it is hard to imagine a Mexican, Szechuan, or Indian dinner without chiles, these characteristic cuisine elements are a relatively recent ...
Victor A, Albert, Tien-Hao, Chang
openaire   +2 more sources

Convergent genomic trajectories shape adaptation to life on land across animal lineages

Nature Communications
How animals repeatedly adapted to life on land is a central question in evolutionary biology. While terrestrialisation occurred independently across animal phyla, it remains unclear whether shared genomic mechanisms underlie these transitions.
Gemma I. Martínez-Redondo, Klara Eleftheriadi, Judit Salces-Ortiz, Nuria Escudero, Fernando Ángel Fernández-Álvarez, Belén Carbonetto, Carlos Vargas-Chávez, Raquel García-Vernet, Javier Palma-Guerrero, Libe Rentería, Iñaki Rojo, Cristina Chiva, Eduard Sabidó, Aureliano Bombarely, Rosa Fernández   +14 more
doaj   +1 more source

Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces

Nature Communications, 2023
Here, the authors describe the geographies, hosts, substrates, and phylogenetic relationships for 1,794 Saccharomyces strains. They provide insight into the genetic and phenotypic diversity in the genus, not seen through prior work focused on the model ...
David Peris, Emily J. Ubbelohde, Meihua Christina Kuang, Jacek Kominek, Quinn K. Langdon, Marie Adams, Justin A. Koshalek, Amanda Beth Hulfachor, Dana A. Opulente, David J. Hall, Katie Hyma, Justin C. Fay, Jean-Baptiste Leducq, Guillaume Charron, Christian R. Landry, Diego Libkind, Carla Gonçalves, Paula Gonçalves, José Paulo Sampaio, Qi-Ming Wang, Feng-Yan Bai, Russel L. Wrobel, Chris Todd Hittinger   +22 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Evolution signatures in genome network properties [PDF]

, 2011
Genomes maybe organized as networks where protein-protein association plays the role of network links. The resulting networks are far from being random and their topological properties are a consequence of the underlying mechanisms for genome evolution ...
Rodrigo Dalmolin, Mauro Castro, Ricardo Ferreira, José Luiz Rybarczyk-Filho, Rita de Almeida, Jose Claudio Moreira, Leonardo Brunnet   +6 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology
Over several decades, therapeutic advances have transformed oncology, yet for many tumour types, survival improvements have been incremental, with substantial treatment‐related morbidity. A decisive pivot in oncology, from treating established malignancy
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

The Grayling Genome Reveals Selection on Gene Expression Regulation after Whole-Genome Duplication [PDF]

, 2018
Whole-genome duplication (WGD) has been a major evolutionary driver of increased genomic complexity in vertebrates. One such event occurred in the salmonid family ∼80 Ma (Ss4R) giving rise to a plethora of structural and regulatory duplicate-driven ...
Leif Asbjørn Vøllestad, Sissel Jentoft, Varadharajan, Srinidhi, Kjetill S Jakobsen, Sandve, Simen R., Mulugeta, Teshome D., Teshome D Mulugeta, Jakobsen, Kjetill Sigurd, Mulugeta, Teshome Dagne, Hvidsten, Torgeir R.,, Sandve, Simen Rød, Simen R Sandve, Gillard, Gareth B., Hvidsten, Torgeir R., Torgeir R Hvidsten, Gillard, Gareth Benjamin, Srinidhi Varadharajan, Ole K Tørresen, Tørresen, Ole K., Gareth B Gillard, Vøllestad, Leif Asbjørn, Jentoft, Sissel, Nederbragt, Alexander J., Alexander J Nederbragt, Jakobsen, Kjetill S., Nederbragt, Alexander Johan, Lien, Sigbjørn, Hvidsten, Torgeir Rhoden, Sigbjørn Lien   +28 more
core   +1 more source

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

Nature Communications
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova   +18 more
doaj   +1 more source

Accumulation of genetic variants associated with immunity in the selective breeding of broilers

BMC Genetics, 2020
Background To satisfy an increasing demand for dietary protein, the poultry industry has employed genetic selection to increase the growth rate of broilers by over 400% in the past 50 years. Although modern broilers reach a marketable weight of ~ 2 kg in
Angela Zou, Kerry Nadeau, Pauline W. Wang, Jee Yeon Lee, David S. Guttman, Shayan Sharif, Doug R. Korver, John H. Brumell, John Parkinson   +8 more
doaj   +1 more source