Results 51 to 60 of about 3,706,718 (308)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evolution of the chloroplast genome [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003
We discuss the suggestion that differences in the nucleotide composition between plastid and nuclear genomes may provide a selective advantage in the transposition of genes from plastid to nucleus. We show that in the adenine, thymine (AT)–rich genome of Borrelia burgdorferi several genes ...
Christopher J, Howe, Adrian C, Barbrook, V Lila, Koumandou, R Ellen R, Nisbet, Hamish A, Symington, Tom F, Wightman   +5 more
openaire   +2 more sources

Chloroplast sequence variation and the efficacy of peptide nucleic acids for blocking host amplification in plant microbiome studies

Microbiome, 2018
Background The ability to efficiently characterize microbial communities from host individuals can be limited by co-amplification of host organellar sequences (mitochondrial and/or plastid), which share a common ancestor and thus sequence similarity with
Connor R. Fitzpatrick, Patricia Lu-Irving, Julia Copeland, David S. Guttman, Pauline W. Wang, David A. Baltrus, Katrina M. Dlugosch, Marc T. J. Johnson   +7 more
doaj   +1 more source

Germline ancestry influences the evolutionary disease course in lung adenocarcinomas

Evolutionary Applications, 2020
Precision medicine relies on targeting specific somatic alterations present in a patient's tumor. However, the extent to which germline ancestry may influence the somatic burden of disease has received little attention.
Alina Schenk, Saioa López, Maik Kschischo, Nicholas McGranahan   +3 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

East-west divergence and metabolic differentiation in celery domestication

Nature Communications
Celery (Apium graveolens) is a globally cultivated vegetable renowned for its health-promoting and nutraceutical benefits. Exploring its genomic and metabolic diversity can help to facilitate breeding selection.
Chenhao Wang, Mengyi Zhang, Qinglong Xu, Xiangyang Du, Jianeng Che, Kuangtian Xu, Lei Ge, Xiao Li, Zhongyuan Hu, Jinghua Yang, Xinsheng Wu, Mingfang Zhang, Xiaolong Lyu   +12 more
doaj   +1 more source

Chemical genetics and strigolactone perception [version 1; referees: 2 approved]

F1000Research, 2017
Strigolactones (SLs) are a collection of related small molecules that act as hormones in plant growth and development. Intriguingly, SLs also act as ecological communicators between plants and mycorrhizal fungi and between host plants and a collection of
Shelley Lumba, Michael Bunsick, Peter McCourt   +2 more
doaj   +1 more source

Effect of sequence depth and length in long-read assembly of the maize inbred NC358

Nature Communications, 2020
Sequence depth and read length determine the quality of genome assembly. Here, the authors leverage a set of PacBio reads to develop guidelines for sequencing and assembly of complex plant genomes in order to allocate finite resources using maize as an ...
Shujun Ou, Jianing Liu, Kapeel M. Chougule, Arkarachai Fungtammasan, Arun S. Seetharam, Joshua C. Stein, Victor Llaca, Nancy Manchanda, Amanda M. Gilbert, Sharon Wei, Chen-Shan Chin, David E. Hufnagel, Sarah Pedersen, Samantha J. Snodgrass, Kevin Fengler, Margaret Woodhouse, Brian P. Walenz, Sergey Koren, Adam M. Phillippy, Brett T. Hannigan, R. Kelly Dawe, Candice N. Hirsch, Matthew B. Hufford, Doreen Ware   +23 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Universal Features in the Genome-level Evolution of Protein Domains [PDF]

, 2008
Protein domains are found on genomes with notable statistical distributions, which bear a high degree of similarity. Previous work has shown how these distributions can be accounted for by simple models, where the main ingredients are probabilities of ...
Bruno Bassetti, Alessandro L. Sellerio, Philip D. Heijning, Marco Cosentino Lagomarsino, M. Cosentino Lagomarsino, B.F. Bassetti, P. D. Heijning, A. L. Sellerio   +7 more
core   +1 more source