Results 61 to 70 of about 3,706,718 (308)
Genome evolution in Caenorhabditis [PDF]
Briefings in Functional Genomics and Proteomics, 2008 Since the completion of the Caenorhabditis elegans genome sequence 10 years ago, efforts of the large community of C. elegans geneticists have resulted in a high-quality annotation of the structures and sequence relatedness of nearly all the protein encoding and RNA genes. Based on increasingly accurate gene counts in other species, it now appears that
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Bioengineering & Translational MedicineWe present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response.
Christopher P. Tostado +7 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The evolution of the human genome [PDF]
Current Opinion in Genetics & Development, 2015 Human genomes hold a record of the evolutionary forces that have shaped our species. Advances in DNA sequencing, functional genomics, and population genetic modeling have deepened our understanding of human demographic history, natural selection, and many other long-studied topics.
Corinne N, Simonti, John A, Capra
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Cell line-matched reference enables high-precision functional genomics
Nature CommunicationsComparative analyses of newly available human genome assemblies highlight extensive variation that peaks at centromeres. Reliance on a single generic reference genome can thus hinder whole-genome analysis of sequencing data derived from laboratory cell ...
Luca Corda +9 more
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Fusion/fission protein family identification in Archaea
mSystemsThe majority of newly discovered archaeal lineages remain without a cultivated representative, but scarce experimental data from the cultivated organisms show that they harbor distinct functional repertoires.
Anastasiia Padalko +2 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells
Non-Coding RNABackground/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs.
Olga R. Borodulina +4 more
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The microbes we eat: abundance and taxonomy of microbes consumed in a day’s worth of meals for three diet types [PDF]
PeerJ, 2014 Far more attention has been paid to the microbes in our feces than the microbes in our food. Research efforts dedicated to the microbes that we eat have historically been focused on a fairly narrow range of species, namely those which cause disease and ...
Jenna M. Lang +2 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source