Results 71 to 80 of about 3,706,718 (308)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genome size versus genome assemblies: Are the genomes truly expanded in polyploid fungal symbionts?

, 2020
Each day, as the amount of genomic data and bioinformatics resources grows, researchers are increasingly challenged with selecting the most appropriate approach to analyze their data. In addition, the opportunity to undertake comparative genomic analyses
Kooij, Pepijn W. [UNESP], Pellicer, Jaume   +1 more
core   +1 more source

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081 [PDF]

, 2014
This work was supported by The Wellcome Trust.The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague.
Maddison, Mark, Abdellah, Zahra, Dougan, Gordon, Howard, Sarah, Quail, Michael A., Parkhill, Julian, Prentice, Michael B., Challis, Gregory L., Mungall, Karen, Chillingworth, Tracey, Moule, Sharon, Sanders, Mandy, Churcher, Carol, Thomson, Nicholas R., Wren, Brendan W., Whitehead, Sally, Brooks, Karen, Jagels, Kay, Feltwell, Theresa, Holden, Matthew T. G., Crossman, Lisa, Hauser, Heidi   +21 more
core   +4 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys rosea

, 2015
Clonostachys rosea is a mycoparasitic fungus that can control several important plant diseases. Here, we report on the genome sequencing of C. rosea and a comparative genome analysis, in order to resolve the phylogenetic placement of C.
Brandström Durling, Mikael,, Sveriges lantbruksuniversitet., Buchvaldt Amby, Daniel,, Tzelepis, Georgios,, Jensen, Dan Funck,, Dubey, Mukesh,, Karlsson, Magnus,   +6 more
core   +1 more source

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Bastiaansen John WM, Nie, H., Nie Haisheng, Crooijmans, R.P.M.A., Groenen, M.A.M., Groenen Martien AM, Bastiaansen, J.W.M., Crooijmans Richard PMA, Megens, H.J.W.C., Megens Hendrik-Jan   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Local adaptation and the evolution of genome architecture in threespine stickleback.

, 2022
Theory predicts that local adaptation should favour the evolution of a concentrated genetic architecture, where the alleles driving adaptive divergence are tightly clustered on chromosomes. Adaptation to marine vs.
Takahashi, Hiroshi, Ehrlich, Rachel L, Yeaman, Sam, Rodríguez Ramírez, Carlos Ernesto, Kitano, Jun, Kakioka, Ryo, Lindtke, Dorothea, Li, Qiushi, Chang Mell, Joshua, Toyoda, Atsushi   +9 more
core   +1 more source

Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure

Microbiome, 2022
Background The emergence of antimicrobial resistance is a major threat to global health and has placed pressure on the livestock industry to eliminate the use of antibiotic growth promotants (AGPs) as feed additives.
Angela Zou, Kerry Nadeau, Xuejian Xiong, Pauline W. Wang, Julia K. Copeland, Jee Yeon Lee, James St. Pierre, Maxine Ty, Billy Taj, John H. Brumell, David S. Guttman, Shayan Sharif, Doug Korver, John Parkinson   +13 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source