Results 91 to 100 of about 3,706,718 (308)

Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

npj Breast Cancer, 2023
Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer.
Lukas Beumers, Efstathios-Iason Vlachavas, Simone Borgoni, Luisa Schwarzmüller, Luca Penso-Dolfin, Birgitta E. Michels, Emre Sofyali, Sara Burmester, Daniela Heiss, Heike Wilhelm, Yosef Yarden, Dominic Helm, Rainer Will, Angela Goncalves, Stefan Wiemann   +14 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The promise of genomics in the study of plant-pollinator interactions [PDF]

, 2013
Flowers exist in exceedingly complex fitness landscapes, in which subtle variation in each trait can affect the pollinators, herbivores and pleiotropically linked traits in other plant tissues.
Clare, EL, Clare, Elizabeth L, Schiestl, Florian P, Chittka, Lars, Leitch, AR, Schiestl, FP, Chittka, L, Leitch, Andrew R   +7 more
core   +1 more source

The reference genome of the human diploid cell line RPE-1

Nature Communications
Recent technological advances have facilitated the assembly of telomere-to-telomere (T2T) genomes. The current T2T CHM13 showcases the complete architecture of the human genome, yet its use in functional experiments is limited by discrepancies with the ...
Emilia Volpe, Alessio Colantoni, Luca Corda, Elena Di Tommaso, Franca Pelliccia, Riccardo Ottalevi, Andrea Guarracino, Danilo Licastro, Luigi Faino, Mattia Capulli, Giulio Formenti, Evelyne Tassone, Simona Giunta   +12 more
doaj   +1 more source

Ere, a Family of Short Interspersed Elements in the Genomes of Odd-Toed Ungulates (Perissodactyla)

Animals
Short Interspersed Elements (SINEs) are eukaryotic retrotransposons transcribed by RNA polymerase III (pol III). Many mammalian SINEs (T+ SINEs) contain a polyadenylation signal (AATAAA), a pol III transcription terminator, and an A-rich tail in their 3′-
Ilia G. Ustyantsev, Sergey A. Kosushkin, Olga R. Borodulina, Nikita S. Vassetzky, Dmitri A. Kramerov   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa

, 2014
The unicellular eukaryotic assemblage Discoba (Excavata) comprises four lineages: the Heterolobosea, Euglenozoa, Jakobida and Tsukubamonadida. Discoba has been considered as a key assemblage for understanding the early evolution of mitochondrial (mt ...
Nishimura, Y., Brown, M. W., Kamikawa, R., Ishida, K. I., Roger, A. J., Hashimoto, T., Inagaki, Y., Ishikawa, S. A., Kolisko, M., Yabuki, A.   +9 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

An agent-based modelling framework to study growth mechanisms in EGFR-L858R mutant cell alveolar type II cells

Royal Society Open Science
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically ...
Helena Coggan, Clare E. Weeden, Philip Pearce, Mohit P. Dalwadi, Alastair Magness, Charles Swanton, Karen M. Page   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source