Results 101 to 110 of about 3,706,718 (308)

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-   +10 more
core   +1 more source

The effect of Wolbachia on gene expression in Drosophila paulistorum and its implications for symbiont-induced host speciation

BMC Genomics, 2019
Background The Neotropical fruit fly Drosophila paulistorum (Diptera: Drosophilidae) is a species complex in statu nascendi comprising six reproductively isolated semispecies, each harboring mutualistic Wolbachia strains. Although wild type flies of each
Guilherme C. Baião, Daniela I. Schneider, Wolfgang J. Miller, Lisa Klasson   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Evolution of genome architecture [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Charles Darwin believed that all traits of organisms have been honed to near perfection by natural selection. The empirical basis underlying Darwin's conclusions consisted of numerous observations made by him and other naturalists on the exquisite adaptations of animals and plants to their natural habitats and on the impressive results of artificial ...
openaire   +2 more sources

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. [PDF]

, 2006
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague.
Maddison, Mark, Abdellah, Zahra, Quail, Michael A, Dougan, Gordon, Howard, Sarah, Wren, Brendan W, Parkhill, Julian, Mungall, Karen, Chillingworth, Tracey, Moule, Sharon, Holden, Matthew TG, Challis, Gregory L, Sanders, Mandy, Prentice, Michael B, Churcher, Carol, Thomson, Nicholas R, Whitehead, Sally, Brooks, Karen, Jagels, Kay, Feltwell, Theresa, Crossman, Lisa, Hauser, Heidi   +21 more
core   +3 more sources

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Nature Communications
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear.
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton   +47 more
doaj   +1 more source

Crowdfunding Campaigns Help Researchers Launch Projects and Generate Outreach

Journal of Microbiology & Biology Education, 2016
Organizers of participatory research (citizen science) projects can generate funds and outreach through crowdfunding. Here we provide insights from three successful science crowdfunding campaigns recently completed on Indiegogo, Experiment, and ...
Katherine Dahlhausen, Bethany L. Krebs, Jason V. Watters, Holly H. Ganz   +3 more
doaj   +1 more source

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Nature Communications, 2020
The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour ...
Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton   +19 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production

Biotechnology for Biofuels, 2017
Background Lignocellulosic biomass is a common resource across the globe, and its fermentation offers a promising option for generating renewable liquid transportation fuels.
David Peris, Ryan V. Moriarty, William G. Alexander, EmilyClare Baker, Kayla Sylvester, Maria Sardi, Quinn K. Langdon, Diego Libkind, Qi-Ming Wang, Feng-Yan Bai, Jean-Baptiste Leducq, Guillaume Charron, Christian R. Landry, José Paulo Sampaio, Paula Gonçalves, Katie E. Hyma, Justin C. Fay, Trey K. Sato, Chris Todd Hittinger   +18 more
doaj   +1 more source