Results 121 to 130 of about 3,706,718 (308)

The low recombining pericentromeric region of barley restricts gene diversity and evolution but not gene expression [PDF]

, 2014
The low-recombining pericentromeric region of the barley genome contains roughly a quarter of the genes of the species, embedded in low recombining DNA that is rich in repeats and repressive chromatin signatures.
Dhillon, Taniya, Milne, Iain, Baker, Katie, Colas, Isabelle, Bayer, Micha, Russell, Joanne, Marshall, David, Waugh, Robbie, Dreißig, Steven, Flavell, Andrew J., Ramsay, Luke, Steffenson, Brian, Stephen, Gordon, Dressig, Steven, Hedley, Pete E., Waugh, Robbie; id_orcid, Cook, Nicola, Morris, Jenny   +17 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Telomeres and genomic evolution [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2018
The terminal regions of eukaryotic chromosomes, composed of telomere repeat sequences and sub-telomeric sequences, represent some of the most variable and rapidly evolving regions of the genome. The sub-telomeric regions are characterized by segmentally duplicated repetitive DNA elements, interstitial telomere repeat sequences and families of variable ...
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Physical mapping and refinement of the painted turtle genome (chrysemys picta) inform amniote genome evolution and challenge turtle-bird chromosomal conservation [PDF]

, 2015
Comparative genomics continues illuminating amniote genome evolution, but for many lineages our understanding remains incom-plete. Here, we refine the assembly (CPI 3.0.3 NCBI AHGY00000000.2) and develop a cytogenetic map of the painted turtle (Chrysemys
Daleen Badenhorst, Janes, Daniel E, Edwards, Scott, Patrick Minx, Warren, Wesley, Hillier, LaDeana W., Hillier, LaDeana W, Minx, Patrick, Srihari Radhakrishnan, Valenzuela, Nicole, Scott V. Edwards, Janes, Daniel E., Ladeana W. Hillier, Janes, Daniel, Daniel E. Janes, Montiel, Eugenia, Yingjia Shen, Montiel, Eugenia Elisabet, Robert Literman, Badenhorst, Daleen, Shen, Yingjia, Literman, Robert, Nicole Valenzuela, Hillier, LaDeana, Shen, Yingia, Edwards, Scott V, Warren, Wesley C, Wesley C. Warren, Warren, Wesley C., Eugenia Elisabet Montiel, Radhakrishnan, Srihari   +30 more
core   +1 more source

Identification of Cyclin L1 as a Host Factor Regulating Hepatitis B Virus Replication

Viruses
Background and Aims: Understanding regulatory interactions between hepatitis B virus (HBV) and host factors is essential for the development of next generation host-directed antiviral therapies and the achievement of a functional HBV cure.
Collins Oduor Owino, Balakrishnan Chakrapani Narmada, Gian Yi Lin, Pauline Poh Kim Aw, Nivrithi Ganesh, Jovi Tan Siying, Marie-Laure Plissonnier, Thangavelu Thangavelu Matan, Niranjan Shirgaonkar, Pablo Bifani, Massimo Levrero, Giridharan Periyasamy, Seng Gee Lim, Ramanuj DasGupta   +13 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The animal in the genome: comparative genomics and evolution [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
Comparisons between completely sequenced metazoan genomes have generally emphasized how similar their encoded protein content is, even when the comparison is between phyla. Given the manifest differences between phyla and, in particular, intuitive notions that some animals are more complex than others, this creates something of a ...
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source