Results 221 to 230 of about 874,950 (354)

The Evolution of Orphan Regions in Genomes of a Fungal Pathogen of Wheat [PDF]

, 2016
Clémence Plissonneau, Alessandra Stürchler, Daniel Croll   +2 more
openalex   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Phylogenetic position and mitochondrial genome evolution of "orphan" eukaryotic lineages. [PDF]

iScience
Zlatogursky V, Boscaro V, Lax G, Wanntorp M, Pohl N, Burki F, Keeling PJ.   +6 more
europepmc   +2 more sources

Genome-wide identification, phylogeny, evolution, and expression patterns of MtN3/saliva/SWEET genes and functional analysis of BcNS in Brassica rapa

, 2018
Liming Miao, Yanxia Lv, Lijun Kong, Qizhen Chen, Chaoquan Chen, Jia Li, Fanhuan Zeng, Shenyun Wang, Jianbin Li, Li Huang, Jiashu Cao, Xiaolin Yu   +11 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Biogeographical and phylogenetic constraints on horizontal gene transfer and genome evolution in <i>Streptomyces</i>. [PDF]

Microbiol Spectr
Hariharan J, Andam CP, Buckley DH.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Evolutionary history and climate-driven dynamics of transposable elements has shaped genome evolution in the Coffea genus. [PDF]

Sci Rep
Dupeyron M, Gonzalez-Garcia L, Orozco-Arias S, Bezandry R, Raharimalala N, Pereira LFP, Crouzillat D, De Block P, Fournier C, Bellanger L, Descombes P, Hamon P, Domingues DS, Guyot R.   +13 more
europepmc   +1 more source

Development and use of RADseq markers to study the impact of Wolbachia on the evolution of mitochondrial genomes in Arthropods

, 2015
Marie Cariou
openalex   +1 more source

Genome-wide Identification, Classification, Molecular Evolution and Expression Analysis of Malate Dehydrogenases in Apple [PDF]

, 2018
Baiquan Ma, Yangyang Yuan, Meng Gao, Libo Xing, Cuiying Li, Mingjun Li, Fengwang Ma   +6 more
openalex   +1 more source