Results 211 to 220 of about 3,706,718 (308)

Comparative genome analysis and genome evolution

, 2002
This thesis described a collection of bioinformatic analyses on complete genome sequence data. We have studied the evolution of gene content and find that vertical inheritance dominates over horizontal gene trasnfer, even to the extent that we can use the gene content to make genome phylogenies.
openaire   +2 more sources

Telomere-to-telomere genome assembly of Metarhizium acridum provides insights into Metarhizium genome evolution. [PDF]

BMC Genomics
Zhao Q, Sun X, Li X, Yang C, Wang G, Zhang Z, Feng S, Dong H, Tu X.   +8 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Elevated retrocopy burden and sloth-specific expansions illuminate mammalian genome evolution. [PDF]

BMC Biol
Uliano-Silva M, da Conceição HB, Mercuri RLV, Winkler S, Guardia GDA, Myers E, McCarthy S, Tracey A, Suh A, Blaxter M, Galante PAF, Mazzoni CJ.   +11 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Comparing chloroplast genomes of Tulipa species: genome evolution and phylogenomic implications. [PDF]

BMC Genomics
Ju X, Shi G, Qin D, Ma Y, He T.
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Global phylogenomics of Bordetella pertussis ST2 reveals regional heterogeneity in China and lineage-specific genome evolution. [PDF]

BMC Genomics
Qi M, Zhou W, Ye H, Lei D, Dong X, Wu X.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Transposable elements as drivers of genome evolution in Drosophila virilis. [PDF]

Nucleic Acids Res
Rezvykh AP, Kulikova DA, Zelentsova ES, Protsenko L, Bespalova AV, Guseva IO, Blumenstiel JP, Evgen'ev MB, Funikov SY.   +8 more
europepmc   +1 more source