Results 41 to 50 of about 874,950 (354)

Effect of sequence depth and length in long-read assembly of the maize inbred NC358

Nature Communications, 2020
Sequence depth and read length determine the quality of genome assembly. Here, the authors leverage a set of PacBio reads to develop guidelines for sequencing and assembly of complex plant genomes in order to allocate finite resources using maize as an ...
Shujun Ou, Jianing Liu, Kapeel M. Chougule, Arkarachai Fungtammasan, Arun S. Seetharam, Joshua C. Stein, Victor Llaca, Nancy Manchanda, Amanda M. Gilbert, Sharon Wei, Chen-Shan Chin, David E. Hufnagel, Sarah Pedersen, Samantha J. Snodgrass, Kevin Fengler, Margaret Woodhouse, Brian P. Walenz, Sergey Koren, Adam M. Phillippy, Brett T. Hannigan, R. Kelly Dawe, Candice N. Hirsch, Matthew B. Hufford, Doreen Ware   +23 more
doaj   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Draft genome sequence of Pseudomonas moraviensis R28-S [PDF]

, 2014
We report the draft genome sequence of Pseudomonas moraviensis R28-S, isolated from the municipal wastewater treatment plant of Moscow, ID. The strain carries a native mercury resistance plasmid, poorly maintains introduced IncP-1 antibiotic resistance ...
De Gelder, Leen, De Vos, Paul, Hughes, Julie, Hunter, Samual S, Loftie-Eaton, Wesley, Settles, Matthew L, Stragier, Pieter, Top, Eva M, Yano, Hirukazo   +8 more
core   +1 more source

An AI‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response

Bioengineering & Translational Medicine
We present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response.
Christopher P. Tostado, Lucas Xian Da Ong, Joel Jia Wei Heng, Carlo Miccolis, Shumei Chia, Justine Jia Wen Seow, Yi‐Chin Toh, Ramanuj DasGupta   +7 more
doaj   +1 more source

The microbes we eat: abundance and taxonomy of microbes consumed in a day’s worth of meals for three diet types [PDF]

PeerJ, 2014
Far more attention has been paid to the microbes in our feces than the microbes in our food. Research efforts dedicated to the microbes that we eat have historically been focused on a fairly narrow range of species, namely those which cause disease and ...
Jenna M. Lang, Jonathan A. Eisen, Angela M. Zivkovic   +2 more
doaj   +2 more sources

Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora. [PDF]

, 2015
BACKGROUND: Downy mildews are the most speciose group of oomycetes and affect crops of great economic importance. So far, there is only a single deeply-sequenced downy mildew genome available, from Hyaloperonospora arabidopsidis.
Bode, Helge B, Cano, Liliana M, Dep Biologie, Evangelisti, Edouard, Govers, Francine, Judelson, Howard, Kamoun, Sophien, Kemen, Eric, Kitner, Miloslav, Klein, Joël, Meijer, Harold J G, Oome, Stan, Plant Microbe Interactions, Sambles, Christine, Schornack, Sebastian, Sharma, Rahul, Spring, Otmar, Studholme, David J, Sub Plant-Microbe Interactions, Thines, Marco, Van den Ackerveken, Guido, van den Hoogen, D Johan, Win, Joe, Xia, Xiaojuan, Zipper, Reinhard   +24 more
core   +5 more sources

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Cell line-matched reference enables high-precision functional genomics

Nature Communications
Comparative analyses of newly available human genome assemblies highlight extensive variation that peaks at centromeres. Reliance on a single generic reference genome can thus hinder whole-genome analysis of sequencing data derived from laboratory cell ...
Luca Corda, Emilia Volpe, Hamza Dallali, Elena Di Tommaso, Alessio Colantoni, Andrea Guarracino, Sai Swaroop Chittoor, Mattia Capulli, Evelyne Tassone, Simona Giunta   +9 more
doaj   +1 more source

Fusion/fission protein family identification in Archaea

mSystems
The majority of newly discovered archaeal lineages remain without a cultivated representative, but scarce experimental data from the cultivated organisms show that they harbor distinct functional repertoires.
Anastasiia Padalko, Govind Nair, Filipa L. Sousa   +2 more
doaj   +1 more source

Evolution of genome size in asexual populations

, 2015
Genome sizes have evolved to vary widely, from 250 bases in viroids to 670 billion bases in amoeba. This remarkable variation in genome size is the outcome of complex interactions between various evolutionary factors such as point mutation rate ...
Adami, Christoph, Gupta, Aditi, LaBar, Thomas, Miyagi, Michael   +3 more
core   +1 more source