Results 131 to 140 of about 141,521 (289)
Using Apache Spark on genome assembly for scalable overlap-graph reduction
Human Genomics, 2019 Background De novo genome assembly is a technique that builds the genome of a specimen using overlaps of genomic fragments without additional work with reference sequence.
Alexander J. Paul +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Coverage graphs of reads mapped to the three segments of the CCHF reference genome. [PDF]
, 2016 Coverage graphs of reads mapped to the three segments of the CCHF reference genome.
Stuart D. Dowall (534412) +9 more
core +1 more source
TIPE: A Bounded and Signature-Aware Framework for Path Construction in Genome Graphs
IEEE AccessGraph-based representations are increasingly used to model genomic variation, enabling richer descriptions than linear reference sequences. However, scalable enumeration and indexing of paths in such graphs remain challenging due to the combinatorial ...
Dimitris Kalatzis
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Fitting a geometric graph to a protein-protein interaction network [PDF]
, 2008 Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between network structure and biological function as well as into evolution.
Higham, Desmond J. +2 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]
, 2010 Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Data structures of genome and protein sequences indexing
Iranian Journal of Information Processing & Management, 2016 Data structure is a tool for storage and retrieval of information which is named logic and mathematic way of specific data organization. various sequences of genes and proteins in various creatures increases the amount of data in genome databases, and ...
Adeleh asadi
doaj