Results 121 to 130 of about 141,521 (289)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A space efficient representation for sparse de Bruijn subgraphs [PDF]

, 2008
Quitzau JAA, Stoye J. A space efficient representation for sparse de Bruijn subgraphs. Forschungsberichte der Technischen Fakultät, Abteilung Informationstechnik / Universität Bielefeld.
Quitzau, José Augusto Amgarten, Stoye, Jens ; https://orcid.org/   +1 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Assembly complexity of prokaryotic genomes using short reads

BMC Bioinformatics, 2010
Background De Bruijn graphs are a theoretical framework underlying several modern genome assembly programs, especially those that deal with very short reads.
Pop Mihai, Schatz Michael C, Kingsford Carl   +2 more
doaj   +1 more source

Constructing small genome graphs via string compression. [PDF]

Bioinformatics, 2021
Qiu Y, Kingsford C.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Directional gene flow and ecological separation in Yersinia enterocolitica [PDF]

, 2015
Yersinia enterocolitica is a common cause of food-borne gastroenteritis worldwide. Recent work defining the phylogeny of the genus Yersinia subdivided Y. enterocolitica into six distinct phylogroups. Here, we provide detailed analyses of the evolutionary
Jukka Corander, Simon Harris, Jukka Corander (105139), Miquette Hall (769338), Alan McNally, Sandra Reuter, Hall, M, Lu Cheng, Reuter, Sandra, De Been, M, Reuter, S, Corander, Jukka, Mark de Been (188325), Miquette Hall, Harris, S, Harris, Simon, McNally, A, de Been, Mark, Lu Cheng (769337), Corander, J, Simon Harris (137272), Mark de Been, Hall, Miquette, Cheng, L, Alan Mcnally (511193), Nicholas R. Thomson, Thomson, Nicholas R, Nicholas R. Thomson (13380), McNally, Alan, Thomson, Nicholas R., Cheng, Lu, McNally, Alan; id_orcid, Thomson, NR, Sandra Reuter (494672)   +33 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Block Graphs in Practice [PDF]

, 2017
Motivated by the rapidly increasing size of genomic databases, code repositories and versioned texts, several compression schemes have been proposed that work well on highly-repetitive strings and also support fast random access: e.g., LZ-End, RLZ, GDC ...
Hoobin, Christopher, Gagie, Travis, Puglisi, Simon J.   +2 more
core   +1 more source

AlfaPang: alignment free algorithm for pangenome graph construction

Algorithms for Molecular Biology
The success of pangenome-based approaches to genomics analysis depends largely on the existence of efficient methods for constructing pangenome graphs that are applicable to large genome collections.
Adam Cicherski, Anna Lisiecka, Norbert Dojer   +2 more
doaj   +1 more source