Results 111 to 120 of about 141,521 (289)
The Vaginal Microbiome: Disease, Genetics and the Environment [PDF]
, 2010 The vagina is an interactive interface between the host and the environment. Its surface is covered by a protective epithelium colonized by bacteria and other microorganisms.
Joao Alves +52 more
core +2 more sources
Superstring Graph: A New Approach for Genome Assembly [PDF]
, 2016 With the increasing impact of genomics in life sciences, the inference of high quality, reliable, and complete genome sequences is becoming critical. Genome assembly remains a major bottleneck in bioin-formatics: indeed, high throughput sequencing apparatus yield millions of short sequencing reads that need to be merged based on their overlaps. Overlap
Cazaux, Bastien +2 more
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
GraphTyper2 enables population-scale genotyping of structural variation using pangenome graphs
Nature Communications, 2019 Structural variants may be omitted in sequence analysis despite their importance in genome variation and phenotypic impact. Here the authors present GraphTyper2, which uses pangenome graphs to genotype structural variants using short-reads and can be ...
Hannes P. Eggertsson +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping [PDF]
, 2004 Hispanic populations are a valuable resource that can and should facilitate the identification of complex trait genes by means of admixture mapping (AM).
Bonilla, C +19 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Whole-genome comparison of two Campylobacter jejuni isolates of the same sequence type reveals multiple loci of different ancestral lineage [PDF]
, 2011 Campylobacter jejuni ST-474 is the most important human enteric pathogen in New Zealand, and yet this genotype is rarely found elsewhere in the world. Insight into the evolution of this organism was gained by a whole genome comparison of two ST-474, flaA
Fearnhead, Paul +33 more
core +1 more source
GROOLS: reactive graph reasoning for genome annotation [PDF]
, 2015 GROOLS (Genomic Rule Oriented Object Logic System) is an expert system to help biologists in the evaluation of genome functional annotation through biological processes like metabolic pathways. Such reasoning is conducted using a Business Rule Management System (BRMS) working on a generic representation of biological knowledge that captures complex ...
Jonathan Mercier, David Vallenet
openaire +1 more source