Results 151 to 160 of about 155,866 (241)

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Genome Instability Precedes Viral Integration in Human Papillomavirus-Transformed Tonsillar Keratinocytes. [PDF]

Mol Cancer Res
Chan K, Tseng C, Milarachi E, Goldrich D, Schneper L, Sheldon K, Aliaga C, Alam S, Chatterjee S, El-Bayoumy K, Meyers C, Goldenberg D, Broach JR.   +12 more
europepmc   +1 more source

Replication DNA polymerases, genome instability and cancer therapies. [PDF]

NAR Cancer, 2023
Strauss JD, Pursell ZF.
europepmc   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Mitochondrial Genome Instability in W303-SK1 Yeast Cytoplasmic Hybrids. [PDF]

Biology (Basel)
Epremyan KK, Burlaka AA, Markova OV, Galkina KV, Knorre DA.   +4 more
europepmc   +1 more source

Retracted: The lncRNA Signatures of Genome Instability to Predict Survival in Patients with Renal Cancer. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

Advanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng, Jiajing Xie, Luqi Wang, Hailong Xie, Tong Zhi, Yujia Guo, Bofeng Zhu, Dong Wang, Yu Chen   +8 more
wiley   +1 more source

Genome Instability and Senescence Are Markers of Cornelia de Lange Syndrome Cells. [PDF]

Cells
Di Nardo M, Krantz ID, Musio A.
europepmc   +1 more source

FGF2 causes genomic instability [PDF]

Nature Reviews Urology, 2018
openaire   +2 more sources