Results 121 to 130 of about 1,940,445 (217)

A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo

Advanced Science, 2020
Lanthipeptides have extensive therapeutic and industrial applications. However, because many are bactericidal, traditional in vivo platforms are limited in their capacity to discover and mass produce novel lanthipeptides as bacterial organisms are often ...
Ran Liu, Yuchen Zhang, Guoqing Zhai, Shuai Fu, Yao Xia, Ben Hu, Xuan Cai, Yan Zhang, Yan Li, Zixin Deng, Tiangang Liu   +10 more
doaj   +1 more source

Genome mining for new enediyne antibiotics. [PDF]

Curr Opin Chem Biol
Enediyne antibiotics epitomize nature's chemical creativity. They contain intricate molecular architectures that are coupled with potent biological activities involving double-stranded DNA scission. The recent explosion in microbial genome sequences has revealed a large reservoir of novel enediynes. However, while hundreds of enediyne biosynthetic gene
Han EJ, Seyedsayamdost MR.
europepmc   +3 more sources

Understanding Learned Models by Identifying Important Features at the Right Resolution

, 2018
In many application domains, it is important to characterize how complex learned models make their decisions across the distribution of instances. One way to do this is to identify the features and interactions among them that contribute to a model's ...
Craven, Mark, Lee, Kyubin, Sood, Akshay
core   +1 more source

Genome Mining for Diazo-Synthesis-Related Genes in Streptomyces sp. CS057 Unveiled the Cryptic Biosynthetic Gene Cluster crx for the Novel 3,4-AHBA-Derived Compound Crexazone 2

Biomolecules
Natural products play a crucial role in drug development, addressing the escalating microbial resistance to antibiotics and the treatment of emerging diseases. Progress in genome sequencing techniques, coupled with the development of bioinformatics tools
Laura Prado-Alonso, Suhui Ye, Ignacio Pérez-Victoria, Ignacio Montero, Pedro Riesco, Francisco Javier Ortiz-López, Jesús Martín, Carlos Olano, Fernando Reyes, Carmen Méndez   +9 more
doaj   +1 more source

WormBase 2012: more genomes, more data, new website [PDF]

, 2012
Since its release in 2000, WormBase (http://www.wormbase.org) has grown from a small resource focusing on a single species and serving a dedicated research community, to one now spanning 15 species essential to the broader biomedical and agricultural ...
Chan, Juancarlos, Chen, Wen J., Fang, Ruihua, Ganesan, Uma, Grove, Christian, Kadam, Snehalata, Kishore, Ranjana, Lee, Raymond, Li, Yuling, Muller, Hans-Michael, Nakamura, Cecilia, Raciti, Daniela, Rangarajan, Arun, Schindelman, Gary, Schwarz, Erich M., Sternberg, Paul W., Van Auken, Kimberly, Wang, Daniel, Wang, Xiaodong, Yook, Karen   +19 more
core  

Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis

, 2014
Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools
A. Holzinger, C. Fraser, C.M. Thomas, C.R. Woese, F. Meyer, G. Carlsson, H. Ochman, H. Rohde, H.C. Neu, J.E. Cooper, J.M. Chan, K.A. Jolley, M.O. Sommer, T. Dagan   +13 more
core   +1 more source

Editorial: The discovery of bioactive natural products: the isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation

Frontiers in Microbiology, 2023
Dewu Zhang, Kalindi Morgan, Ling Liu
doaj   +1 more source

Non-ribosomal Peptide Synthetase Gene Clusters in the Human Pathogenic Fungus Scedosporium apiospermum

Frontiers in Microbiology, 2019
Scedosporium species are opportunistic fungi which preferentially affect patients with underlying conditions such as immunosuppression or cystic fibrosis (CF).
Yohann Le Govic, Yohann Le Govic, Nicolas Papon, Solène Le Gal, Solène Le Gal, Jean-Philippe Bouchara, Jean-Philippe Bouchara, Patrick Vandeputte, Patrick Vandeputte   +8 more
doaj   +1 more source

Educating the educators: Incorporating bioinformatics into biological science education in Malaysia [PDF]

, 2012
Bioinformatics can be defined as a fusion of computational and biological sciences. The urgency to process and analyse the deluge of data created by proteomics and genomics studies has caused bioinformatics to gain prominence and importance. However, its
Hussein, Huszalina, Mohd. Hashim, Siti Zaiton, Salim, Naomie, Shamsir, Mohd. Shahir   +3 more
core  

Mining the mouse genome [PDF]

Nature, 2002
openaire   +3 more sources