Results 121 to 130 of about 80,951 (303)
Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae
Advanced Science, EarlyView.We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang +13 morewiley +1 more sourceTEXT MINING – PREREQUISITE FOR KNOWLEDGE MANAGEMENT SYSTEMS [PDF]
Text mining is an interdisciplinary field with the main purpose of retrieving new knowledge from large collections of text documents. This paper presents the main techniques used for knowledge extraction through text mining and their main areas of ...Dragoº Marcel VESPANcore RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu +13 morewiley +1 more sourceNatural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants
Advanced Science, EarlyView.Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia +10 morewiley +1 more sourceSingle‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development
Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng +9 morewiley +1 more sourceMolecular Genetic Characterization of an Anthrabenzoxocinones Gene Cluster in Streptomyces Sp. FJS31-2 for the Biosynthesis of BE-24566B and Zunyimycin Ale
Molecules, 2016 Genome mining is an effective tool used to discover novel natural products from actinomycetes. Genome sequence analysis of Streptomyces sp. FJS31-2 revealed the presence of one putative type II polyketide gene cluster (ABX), which may correspond to type ...Yuhong Lü, Changwu Yue, Meiyun Shao, Shengyan Qian, Ning Liu, Yuxin Bao, Miao Wang, Minghao Liu, Xiaoqian Li, Yinyin Wang, Ying Huang +10 moredoaj +1 more sourceRHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine
Advanced Science, EarlyView.RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan +12 morewiley +1 more sourceA Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo
Advanced Science, 2020 Lanthipeptides have extensive therapeutic and industrial applications. However, because many are bactericidal, traditional in vivo platforms are limited in their capacity to discover and mass produce novel lanthipeptides as bacterial organisms are often ...Ran Liu, Yuchen Zhang, Guoqing Zhai, Shuai Fu, Yao Xia, Ben Hu, Xuan Cai, Yan Zhang, Yan Li, Zixin Deng, Tiangang Liu +10 moredoaj +1 more sourceGenome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire [PDF]
, 2010 Background: Pythium ultimum (P. ultimum) is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results: The P.Beakes, Gordon W, Lévesque, CA, Cano, L., Puiu, D, Ronald P De Vries, Raffaele, Sylvain, Hostetler, Jessica, Henrissat, B., Paul D Thomas, Phuntmart, Vipaporn, Boore, J.L., Brett R Whitty, Beakes, GW, Whitty, Brett R, Grenville-Briggs, L., Whitty, Brett R., Horner, N, Cano, L, Raffaele, S., Robideau, Gregg P, Steve Ferriera, Tisserat, Ned, Shetty, J, Tisserat, N., Busam, D, Krajaejun, T., Stajich, JE, Holt, C, Yandell, M, Zerillo, MM, C Robin Buell, West, Pieter van, Morris, P., Hamilton, John P, Pedro M Coutinho, Buell, C. Robin, Martin, Frank, Wawra, S, Whitty, B.R., Sucheta Tripathy, Meijer, Harold J. G., Thines, Marco, Buell, C.R., Wawra, Stephan, Win, J, Gregg P Robideau, Gordon W Beakes, Gachon, Claire M. M., Henk Brouwer, Gachon, C.M.M., Ned Tisserat, Susan I Fuerstenberg, Whitty, BR, Busam, Dana, Phuntmart, V., Thomas, P.D., Govers, F, Mark Yandell, Hostetler, J, Marcelo M Zerillo, Gachon, Claire MM, Lévesque, C.A., Neil Horner, Beakes, G.W., Tisserat, N, Dana Busam, Dumas, B., Yandell, M., Horner, Neil, Krajaejun, T, Zerillo, M.M., Joe Win, Edgar Huitema, Tyler, Brett M., Robideau, G.P., Zerillo, M., Zerillo, Marcelo M, Grenville-Briggs, L, Krajaejun, Theerapong, Raffaele, S, Vries, Ronald Peter de, Johnson, J, Theerapong Krajaejun, Coutinho, Pedro, M, Lévesque, C André, Yandell, Mark, Govers, F., Vries, R.P., de, van West, Pieter, Rays HY Jiang, Puiu, Daniela, Boore, JL, Beakes, Gordon W., De Vries, Ronald P., Coutinho, P.M., Gaulin, Elodie, Win, J., Barry Moore, van West, P, Meijer, H.J.G., Meijer, HJG, Lin, H., Wawra, S., Lin, H, Jessica Hostetler, Paul Morris, Lévesque, C. André, Stephan Wawra, Sylvain Raffaele, Laura Grenville-Briggs, Fuerstenberg, S.I., Bernard Dumas, Meijer, Harold JG, Shetty, J., Phuntmart, V, De Vries, R.P., Tripathy, S, Coutinho, Pedro M., Gachon, Claire M M, Moore, B, Thines, M, Claire MM Gachon, Fuerstenberg, SI, Robideau, Gregg P., Henrissat, Bernard, Dumas, B, Huitema, Edgar; id_orcid, Brouwer, Henk, Grenville-Briggs, Laura, Moore, Barry, Hostetler, J., Huitema, E., Liliana Cano, Puiu, D., Coutinho, Pedro,, Hamilton, J.P., Ferriera, Steve, Zerillo, Marcelo M., Marco Thines, Daniela Puiu, Huitema, E, Sophien Kamoun, Henrissat, B, Boore, Jeffrey L., Jiang, Rays HY, Stajich, Jason E, De Vries, Ronald P, Bernard Henrissat, van West, P., Kamoun, Sophien, Gaulin, E, Brouwer, H., Win, Joe, Gaulin, E., West, P., van, Huitema, Edgar, Brouwer, H, Justin Johnson, Jiang, Rays H. Y., Thines, M., Jyoti Shetty, Tripathy, S., Frank Martin, Tyler, Brett M, Buell, C Robin, Jiang, RHY, Buell, CR, Morris, Paul, Govers, Francine, Tyler, B.M., Jason E Stajich, Ferriera, S, Jiang, R.H.Y., John P Hamilton, Martin, F, Meijer, Harold J G, Kamoun, S., Jiang, Rays H Y, Brett M Tyler, Fürstenberg, Susan, Hamilton, John P., Lin, Haining, Horner, N., Elodie Gaulin, Thomas, Paul D, Haining Lin, Robideau, GP, Coutinho, PM, Johnson, Justin, Tyler, BM, Harold JG Meijer, Francine Govers, Fuerstenberg, Susan I, Cano, Liliana, Vipaporn Phuntmart, Stajich, J.E., Moore, B., Holt, Carson, Thomas, Paul D., Holt, C., Hamilton, JP, Gachon, CMM, Shetty, Jyoti, Stajich, Jason E., Carson Holt, Jeffrey L Boore, Coutinho, Pedro M, Martin, F., Boore, Jeffrey L, De Vries, RP, Johnson, J., Pieter van West, Morris, P, Thomas, PD, C André Lévesque, Fuerstenberg, Susan I., Dumas, Bernard, Ferriera, S., Tripathy, Sucheta, Kamoun, S, Busam, D. +220 morecore +1 more source
