Results 151 to 160 of about 1,743,586 (380)

arrayMap: A Reference Resource for Genomic Copy Number Imbalances in Human Malignancies [PDF]

, 2012
Background: The delineation of genomic copy number abnormalities (CNAs) from cancer samples has been instrumental for identification of tumor suppressor genes and oncogenes and proven useful for clinical marker detection. An increasing number of projects have mapped CNAs using high-resolution microarray based techniques. So far, no single resource does
arxiv   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Bioactivities and genome insights of a thermotolerant antibiotics‐producing Streptomyces sp. TM32 reveal its potentials for novel drug discovery

MicrobiologyOpen, 2019
A way to defeat antimicrobial resistance (AMR) crisis is to supply novel drugs to the pharmaceutical industry. This effort leads to a global call for seeking the beneficial microbes from underexplored habitats.
Nareeluk Nakaew, Saisamorn Lumyong, William T. Sloan, Rungroch Sungthong   +3 more
doaj   +1 more source

Mining the Common Heritage of Our DNA: Lessons Learned From Grotius and Pardo [PDF]

, 2006
The Human Genome Project generated oceans of DNA sequence data and spurred a multinational race to grab the bounties of these oceans. In response to these DNA property grabs, UNESCO, drawing upon international law precedents addressing analogous grabs in
Bovenberg, Jasper A.
core   +1 more source

Genome-wide EST data mining approaches to resolving incongruence of molecular phylogenies [PDF]

arXiv, 2006
36 single genes of six plants inferred 18 unique trees using maximum parsimony. Such incongruence is an important issue and how to reconstruct the congruent tree still is one of the most challenges in molecular phylogenetics. For resolving this problem, a genome-wide EST data mining approach was systematically investigated by retrieving a large size of
arxiv  

Deep Learning Combined with Quantitative Structure‒Activity Relationship Accelerates De Novo Design of Antifungal Peptides

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Drug resistance remains a serious threat to human health and the planet's ecology. Using deep learning integrated with quantitative structure‒activity relationship, 49 highly active antifungal peptides are de novo designed. In vitro and in vivo studies demonstrate these peptides' potential to minimize the risk of resistance development in pathogens ...
Kedong Yin, Ruifang Li, Shaojie Zhang, Yiqing Sun, Liang Huang, Mengwan Jiang, Degang Xu, Wen Xu   +7 more
wiley   +1 more source

Information-theoretic Interestingness Measures for Cross-Ontology Data Mining [PDF]

arXiv, 2015
Community annotation of biological entities with concepts from multiple bio-ontologies has created large and growing repositories of ontology-based annotation data with embedded implicit relationships among orthogonal ontologies. Development of efficient data mining methods and metrics to mine and assess the quality of the mined relationships has not ...
arxiv  

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Hispidin is a polyphenolic compound with a variety of biological activities. Herein, a new aldol condensase PheG from Phellinus igniarius (P. igniarius) can catalyze tricetolatone and 3, 4‐dihydroxybenzaldehyde to hispidin. The catalytic mechanism of nucleophilic addition of PheG is determined by MM/GBSA, density functional theory calculation, and site‐
Wanting Zhang, Ruliang Zheng, Weiling Geng, Xinyuan Wu, Xiaojuan Gao, Li Zhou, Zhenyu An, Cheng Liu, Zhijun Song, Hongyan Ji, Hao Yang, Xiuli Wu   +11 more
wiley   +1 more source

Customization of Ethylene Glycol (EG)‐Induced BmoR‐Based Biosensor for the Directed Evolution of PET Degrading Enzymes

Advanced Science, Volume 12, Issue 13, April 3, 2025.
PET degrading enzymes are evolved employing a novel fluorescence high‐throughput screening tool via a performance‐improved ethylene glycol (EG)‐induced BmoR‐based biosensor modified by TF engineering. PET waste is completely depolymerized into its basic units at moderate temperatures.
Min Li, Zhenya Chen, Wuyuan Zhang, Tong Wu, Qingsheng Qi, Yi‐Xin Huo   +5 more
wiley   +1 more source