Results 151 to 160 of about 176,908 (324)

Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe

Chemistry – A European Journal, EarlyView.
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann, Alexander Brachmann, Shurui Mai, Athanasios Markos, Markus Künzler, Jörn Piel, Helma Wennemers   +6 more
wiley   +1 more source

Systems-informed genome mining for electroautotrophic microbial production

, 2022
Jacob M. Hilzinger, Anthony J. Abel
openalex   +1 more source

Selective Modification of the Product Profile of Biocatalytic Hydrolyzed PET via Product‐Specific Medium Engineering

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The product profile of enzymatically hydrolyzed PET can be modified by medium engineering and thereby adapted to a desired product. TPA, MHET or BHET can be forced as the predominant product using a basic pH (blue), 25 % ethylene glycol (EG) and IsPETasewt (green) or ≥25 % EG and LCCICCG (pink), respectively.
Tobias Heinks, Katrin Hofmann, Simon Last, Igor Gamm, Luise Blach, Ren Wei, Uwe T. Bornscheuer, Christof Hamel, Jan von Langermann   +8 more
wiley   +1 more source

Impacts of large herbivores on mycorrhizal fungal communities across the Arctic

Ecography, EarlyView.
Mycorrhizal fungi play an integral role in nutrient and carbon cycling in soils, which may be especially important in the Arctic, one of the world's most soil carbon‐rich regions. Large mammalian herbivores can influence these fungi through their impacts on vegetation and soil conditions, however the strength and prevalence of these interactions in the
Cole G. Brachmann, Martin Ryberg, Brendan R. Furneaux, Anna Rosling, Tinghai Ou, Alf Ekblad, Svetlana Abdulmanova, Isabel C. Barrio, M. Syndonia Bret‐Harte, Hannu Fritze, Laura Gough, Robert D. Hollister, Ingibjörg S. Jónsdóttir, Oula Kalttopää, Elin Lindén, Päivi Mäkiranta, Johan Olofsson, Rauni Partanen, Kirsten A. Reid, Aleksandr Sokolov, Maija S. Sujala, Maja K. Sundqvist, Otso Suominen, Craig E. Tweedie, Amanda Young, Robert G. Björk   +25 more
wiley   +1 more source

Supplemental Dataset for Automated genome mining predicts combinatorial diversity and taxonomic distribution of peptide metallophore structures

, 2022
Zachary L. Reitz
openalex   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Genome Sequencing and Characterization of Bacillus velezensis N23 as Biocontrol Agent against Plant Pathogens

Microorganisms
The overuse of chemical fungicides against fungal pathogens adversely affects soil and plant health, resulting in environmental problems and food safety.
Panlei Yang, Qingchao Zeng, Wenxiao Jiang, Luotao Wang, Jie Zhang, Zhenshuo Wang, Qi Wang, Yan Li   +7 more
doaj   +1 more source

Genome Mining Shows Ubiquitous Presence and Extensive Diversity of Toxin-Antitoxin Systems in Pseudomonas syringae [PDF]

, 2022
Prem P. Kandel, Marina Naumova, Chad Fautt, Ravikumar Patel, Lindsay R. Triplett, Kevin L. Hockett   +5 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source