Results 191 to 200 of about 1,940,445 (217)

Identification of Two Distinct Stereoselective Lysine 5‐Hydroxylases by Genome Mining Based on Alazopeptin Biosynthetic Enzymes

Chemistry
Enzymes that catalyze regioselective and stereoselective hydroxylation of amino acids are useful tools for the synthesis of pharmaceuticals. AzpK is an unprecedented lysine 5‐hydroxylase that is involved in alazopeptin biosynthesis, although its ...
Konstantina Gravvani, Maria Solakidou, M. Louloudi   +2 more
semanticscholar   +1 more source

Recent advances in genome mining and synthetic biology for discovery and biosynthesis of natural products

Critical Reviews in Biotechnology
Natural products have long served as critical raw materials in chemical and pharmaceutical manufacturing, primarily which can provide superior scaffolds or intermediates for drug discovery and development.
Mingpeng Wang, Lei Chen, Zhaojie Zhang, Qinhong Wang   +3 more
semanticscholar   +1 more source

Targeted Discovery of Glycosylated Natural Products by Tailoring Enzyme-Guided Genome Mining and MS-Based Metabolome Analysis.

Journal of the American Chemical Society
Glycosides make up a biomedically important class of secondary metabolites. Most naturally occurring glycosides were isolated from plants and bacteria; however, the chemical diversity of glycosylated natural products in fungi remains largely unexplored ...
Dawei Chen, Zhijun Song, Junjie Han, Ji-mei Liu, Hongwei Liu, Jungui Dai   +5 more
semanticscholar   +1 more source

Genome mining of biosynthetic gene clusters intended for secondary metabolites conservation in actinobacteria.

Microbial Pathogenesis, 2021
Evolution of genome sequencing technology, on the one hand, and advancement of computational genome mining tools, on the other hand, paves way for improvement in predicting secondary metabolites.
Karthick Raja Arulprakasam, Dhanasekaran Dharumadurai   +1 more
semanticscholar   +1 more source

In silico genome mining of potential novel biosynthetic gene clusters for drug discovery from Burkholderia bacteria

Comput. Biol. Medicine, 2021
As an emerging resource, Gram-negative Burkholderia bacteria were able to produce a wide range of bioactive secondary metabolites with potential therapeutic and biotechnological applications.
K. Alam, Md. Mahmudul Islam, Kai Gong, Muhammad Nazeer Abbasi, Ruijuan Li, Youming Zhang, Aiying Li   +6 more
semanticscholar   +1 more source

Mining the genomes of exceptional responders

Nature Reviews Cancer, 2014
The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?
Chang, David K., Grimmond, Sean M., Evans, T. R. Jeffry, Biankin, Andrew V.   +3 more
openaire   +3 more sources

Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity.

Organic Letters, 2021
We conducted global genome mining of 162,672 bacterial genomes and identified 829 cyclodipeptide (CDP) biosynthesis gene clusters (BGC) containing a cytochrome P450 gene.
J. Malit, Wenchao Liu, Aifang Cheng, S. Saha, Ling-Li Liu, P. Qian   +5 more
semanticscholar   +1 more source

The confluence of big data and evolutionary genome mining for the discovery of natural products.

Natural product reports (Print), 2021
This review covers literature between 2003-2021The development and application of genome mining tools has given rise to ever-growing genetic and chemical databases and propelled natural products research into the modern age of Big Data.
M. Chevrette, Athina Gavrilidou, Shrikant S. Mantri, Nelly Sélem-Mojica, N. Ziemert, F. Barona-Gómez   +5 more
semanticscholar   +1 more source

Antimicrobials, drug discovery, and genome mining

Applied Microbiology and Biotechnology, 2012
Over the years, antibiotics have provided an effective treatment for a number of microbial diseases. However recently, there has been an increase in resistant microorganisms that have adapted to our current antibiotics. One of the most dangerous pathogens is methicillin-resistant Staphylococcus aureus (MRSA).
R J, Scheffler, S, Colmer, H, Tynan, A L, Demain, V P, Gullo   +4 more
openaire   +2 more sources

Metagenomics: Mining Environmental Genomes

2013
The use of traditional microbiological culturing methods for the study of microbes had limited success since it has been estimated that 99% of microbes cannot be cultivated easily. Over the past decade, “metagenomics,” which is the culture-independent genomic analysis of microbes, has been developed to overcome these difficulties.
Sheela Srivastava, Nitika Ghosh, Gargi Pal   +2 more
openaire   +1 more source