Results 301 to 310 of about 176,908 (324)

Genome Mining-Based Discovery of Pyrano[2,3-<i>c</i>]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups. [PDF]

Org Lett
Shi Y, Ozaki T, Morishita Y, Taniguchi T, Sato H, Aoyama Y, Sugawara A, Numata K, Fuse T, Matsuda R, Hosotani K, Fukano H, Hoshino Y, Hirabayashi A, Suzuki M, Yasuda J, Yoshikawa R, Hayashi H, Kodama EN, Shimotai Y, Hamamoto H, Davis RA, Asai T.   +22 more
europepmc   +1 more source

Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products. [PDF]

Front Microbiol
Han C, Song A, He Y, Yang L, Chen L, Dai W, Wu Q, Yuan S.   +7 more
europepmc   +1 more source

Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads

Lund G, Mosquito S, Withall DM, Caulfield J, Hughes D, Clark IM, Rudd J, Mauchline TH.   +7 more
europepmc   +1 more source

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Mining the Pseudomonas Genome

2014
Pseudomonas species were targeted early for genomic studies since they were noted for their diverse metabolic capacity, ability to inhabit a wide range of environments and hosts, and include notable human and agriculturally relevant pathogens. As more genomes are sequenced, the power of genome-scale analyses are increasing and a wide range of analyses ...
Geoffrey L, Winsor, Fiona S L, Brinkman
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MINING THE GENOME

Chemical & Engineering News Archive, 2002
Having tackled the human genome, Celera's Gene Myers is now advancing on proteins and drug development. This article discusses Myers' work on developing computational biology for the human genome project. The further development of computational biology for the pharmaceutical industry is also discussed.
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Mining microsatellites in eukaryotic genomes

Trends in Biotechnology, 2007
During recent decades, microsatellites have become the most popular source of genetic markers. More recently, the availability of enormous sequence data for a large number of eukaryotic genomes has accelerated research aimed at understanding the origin and functions of microsatellites and searching for new applications.
Prakash C, Sharma, Atul, Grover, Günter, Kahl   +2 more
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Mining the genomes of exceptional responders

Nature Reviews Cancer, 2014
The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?
Chang, David K., Grimmond, Sean M., Evans, T. R. Jeffry, Biankin, Andrew V.   +3 more
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Antimicrobials, drug discovery, and genome mining

Applied Microbiology and Biotechnology, 2012
Over the years, antibiotics have provided an effective treatment for a number of microbial diseases. However recently, there has been an increase in resistant microorganisms that have adapted to our current antibiotics. One of the most dangerous pathogens is methicillin-resistant Staphylococcus aureus (MRSA).
R J, Scheffler, S, Colmer, H, Tynan, A L, Demain, V P, Gullo   +4 more
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Metagenomics: Mining Environmental Genomes

2013
The use of traditional microbiological culturing methods for the study of microbes had limited success since it has been estimated that 99% of microbes cannot be cultivated easily. Over the past decade, “metagenomics,” which is the culture-independent genomic analysis of microbes, has been developed to overcome these difficulties.
Sheela Srivastava, Nitika Ghosh, Gargi Pal   +2 more
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Using Proteomics to Mine Genome Sequences

Journal of Proteome Research, 2004
We present a method for mining unannotated or annotated genome sequences with proteomic data to identify open reading frames. The region of a genome coding for a protein sequence is identified by using information from the analysis of proteins and peptides with MALDI-TOF mass spectrometry.
Jonathan W, Arthur, Marc R, Wilkins
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