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The Organization of the Bacterial Genome
Annual Review of Genetics, 2008Many bacterial cellular processes interact intimately with the chromosome. Such interplay is the major driving force of genome structure or organization. Interactions take place at different scales—local for gene expression, global for replication—and lead to the differentiation of the chromosome into organizational units such as operons, replichores ...
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An overview on genome organization of marine organisms
Marine Genomics, 2015In this review we will concentrate on some general genome features of marine organisms and their evolution, ranging from vertebrate to invertebrates until unicellular organisms. Before genome sequencing, the ultracentrifugation in CsCl led to high resolution of mammalian DNA (without seeing at the sequence).
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Genome-wide transcription and the implications for genomic organization
Nature Reviews Genetics, 2007Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that most of both strands of the human genome might be transcribed, implying extensive overlap of transcriptional units and regulatory ...
Philipp, Kapranov +2 more
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Organizing the genome: enhancers and insulators
Biochemistry and Cell Biology, 2005Enhancers can activate their target genes over large linear distances. Insulators can delimit the influence of an enhancer to an appropriate target. There are a number of intertwined mechanisms by which the regulatory functions of enhancers and insulators might be carried out at the level of the chromatin fiber.
Hui, Zhao, Ann, Dean
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Organization of chloroplast genomes
Advances in Biophysics, 1986K, Shinozaki, M, Sugiura
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The Spatial Organization of the Human Genome
Annual Review of Genomics and Human Genetics, 2013In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease.
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Understanding 3D Genome Organization by Multidisciplinary Methods
Nature Reviews Molecular Cell Biology, 2021Ivana Jerković, Giacomo Cavalli
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Three-Dimensional Genome Organization in Immune Cell Fate and Function
Nature Reviews Immunology, 2023Ralph Stadhouders +2 more
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Engineering 3D Genome Organization
Nature Reviews Genetics, 2021Lei S Qi, Haifeng Wang, Mengting Han
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