Results 61 to 70 of about 3,886,811 (311)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2020 The Hongyuan breed Yak (Bos grunniens) belongs to a member of t the subfamily Bovinae. We provide a complete mitogenome of B. grunniens and analyze its phylogenetic relationship with other related species.
Lichun Jiang +7 more
doaj +1 more source
Topoisomerase 2β and DNA topology during B cell development
Frontiers in Immunology, 2022 Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes ...
Olivier Papapietro +4 more
doaj +1 more source
Pycnophyes kielensis genome organization.
, 2016 Pycnophyes kielensis genome organization.
Olga S. Kedrova (3226869) +9 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Viruses, 2021 Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored.
Abdul Wahaab +8 more
doaj +1 more source
Genome organization and regulation
Molecular Biology of the Cell, 2013 The broad-ranging topic of this Minisymposium attracted four presentations describing in vivo and in vitro experimental work and two presentations that primarily addressed theoretical aspects of chromatin behavior over long and short length scales. Overall, the focus was very much on chromosomes, with presentations addressing chromosome ends (telomeres)
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
eLife, 2019 Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
Andrey Poleshko +9 more
doaj +1 more source
Unique features of transcription termination and initiation at closely spaced tandem human genes
Molecular Systems Biology, 2022 The synthesis of RNA polymerase II (Pol2) products, which include messenger RNAs or long noncoding RNAs, culminates in transcription termination. How the transcriptional termination of a gene impacts the activity of promoters found immediately downstream
Noa Nissani, Igor Ulitsky
doaj +1 more source