Results 61 to 70 of about 5,189,630 (339)

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

Kerfuffle: a web tool for multi-species gene colocalization analysis [PDF]

, 2013
The evolutionary pressures that underlie the large-scale functional organization of the genome are not well understood in eukaryotes. Recent evidence suggests that functionally similar genes may colocalize (cluster) in the eukaryotic genome, suggesting ...
Aboukhalil, Robert, Atwal, Gurinder S., Fendler, Bernard   +2 more
core   +2 more sources

High-resolution TADs reveal DNA sequences underlying genome organization in flies

Nature Communications, 2017
Despite an abundance of new studies about topologically associating domains (TADs), the role of genetic information in TAD formation is still not fully understood.
Fidel Ramírez, Vivek Bhardwaj, Laura Arrigoni, Kin Chung Lam, B. Grüning, J. Villaveces, B. Habermann, A. Akhtar, T. Manke   +8 more
semanticscholar   +1 more source

Regulation of single-cell genome organization into TADs and chromatin nanodomains

Nature Genetics, 2020
The genome folds into a hierarchy of three-dimensional structures within the nucleus. At the sub-megabase scale, chromosomes form topologically associating domains (TADs)1–4. However, how TADs fold in single cells is elusive. Here, we reveal TAD features
Quentin Szabo, Axelle Donjon, I. Jerković, G. Papadopoulos, T. Cheutin, B. Bonev, E. Nora, B. Bruneau, F. Bantignies, Giacomo Cavalli   +9 more
semanticscholar   +1 more source

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.

Cell, 2019
Several general principles of global 3D genome organization have recently been established, including non-random positioning of chromosomes and genes in the cell nucleus, distinct chromatin compartments, and topologically associating domains (TADs ...
Elizabeth H. Finn, Gianluca Pegoraro, Hugo B. Brandão, Anne-Laure Valton, Marlies E. Oomen, J. Dekker, L. Mirny, T. Misteli   +7 more
semanticscholar   +1 more source

Morphology, Genome Organization, Replication, and Pathogenesis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Coronavirus Disease 2019 (COVID-19), 2020
SARS-CoV-2 is a single-stranded RNA virus of ~30 kb genome size which belongs to genus Coronavirus and family Coronaviridae. SARS-CoV-2 has recently emerged and has been declared as a pandemic by the World Health Organization. Genomic characterization of
Swatantra Kumar, Rajni Nyodu, Vimal K. Maurya, S. K. Saxena   +3 more
semanticscholar   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

FACT depletion demonstrates a role for nucleosome organization in TAD formation

Molecular Systems Biology
Mammalian genomes are organized into distinct chromatin structures, which include small-scale nucleosome arrays and large-scale topologically associating domains (TADs).
Clemens Mauksch, Yi Zhu, Taras Velychko, Spyridoula Sagropoulou, Abrar Aljahani, Shyam Ramasamy, Kristina Žumer, A Marieke Oudelaar   +7 more
doaj   +1 more source

Alterations to nuclear architecture and genome behavior in senescent cells. [PDF]

, 2007
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions.
Abney J.R., Agrelo R., Barboro P., Becker P.B., Bemiller P.M., Benn P.A., Berezney R., Bowman P.D., Bridger J.M., Bridger J.M., C. S. CLEMENTS, Campisi J., Chaly N., Chang K.S., Cremer T., de Lange T., Dell'Orco R.T., Dijkwel P.A., Ferbeyre G., Filesi I., Fisher A.G., Fleischer S., Goldman R.D., Gruenbaum Y., Haque F., Hernandez-Verdun D., Holliday R., Hozak P., I. R. KILL, I. S. MEHTA, J. M. BRIDGER, Kill I.R., Kreth G., Lezhava T., Li Y., M. FIGGITT, Mallette F.A., Manuelidis L., Mazin A.L., Mitsui Y., Mukherjee A.B., Nickerson J., Okabe J., Padiath Q.S., Pawelec G., Petrova N.V., Schardin M., Schulz L., Smilenov L.B., Strouboulis J., Tanabe H., van Driel R., Wang G.S.   +52 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source