Results 11 to 20 of about 1,119,935 (184)

100K Pathogen Genome Project. [PDF]

Genome Announc, 2017
The 100K Pathogen Genome Project is producing draft and closed genome sequences from diverse pathogens. This project expanded globally to include a snapshot of global bacterial genome diversity.
Weimer BC.
europepmc   +3 more sources

Correction: Hsiao et al. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. Biomolecules 2023, 13, 125

Biomolecules, 2023
In the original publication [...]
Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai   +2 more
doaj   +1 more source

Analysis of SARS-CoV-2 genomic epidemiology reveals disease transmission coupled to variant emergence and allelic variation

Scientific Reports, 2021
The spread of SARS-CoV-2 created a pandemic crisis with > 150,000 cumulative cases in > 65 countries within a few months. The reproductive number (R) is a metric to estimate the transmission of a pathogen during an outbreak.
D J Darwin R. Bandoy, Bart C. Weimer
doaj   +1 more source

Molecular tools to monitor health and disease – and lucky coincidences

Upsala Journal of Medical Sciences, 2022
Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease.
Ulf Landegren
doaj   +1 more source

Deciphering Signatures of Mutational Processes Operative in Human Cancer

Cell Reports, 2013
The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov, Serena Nik-Zainal, David C. Wedge, Peter J. Campbell, Michael R. Stratton   +4 more
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Mutational signatures of ionizing radiation in second malignancies

Nature Communications, 2016
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell   +32 more
doaj   +1 more source

Analyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one species

Virulence, 2021
Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological ...
Laura E. Hernández-Juárez, Margarita Camorlinga, Alfonso Méndez-Tenorio, Judith Flores Calderón, B. Carol Huang, DJ Darwin R. Bandoy, Bart C. Weimer, Javier Torres   +7 more
doaj   +1 more source

Draft Genome Sequences of 1,183 Salmonella Strains from the 100K Pathogen Genome Project. [PDF]

, 2017
Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This is the public release of 1,183 Salmonella draft genome sequences as part of the 100K Pathogen Genome Project.
Arabyan, Narine, Chen, Poyin, Chin, Ning, Davis, Matthew, Foutouhi, Azarene, Foutouhi, Soraya, Huang, Bihua C, Kaufman, James, Kong, Nguyet, Ng, Whitney, Storey, Dylan B, Thao, Kao, Weimer, Bart C, Weis, Allison M, Xie, Yi   +14 more
core   +1 more source

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Nature Communications, 2017
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell   +32 more
doaj   +1 more source

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Cell Reports, 2016
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L. Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R. Davies, Patrick S. Tarpey, Peter Van Loo, David C. Wedge, David R. Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Violetta Barbashina, Samuel A.J.R. Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, Gilles Thomas, Andrea L. Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R. Stratton, Peter J. Campbell   +36 more
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