Results 251 to 260 of about 1,073,692 (309)
The Bermuda Triangle: The Pragmatics, Policies, and Principles for Data Sharing in the History of the Human Genome Project. [PDF]
J Hist Biol, 2018 Maxson Jones K +2 more
europepmc +1 more source
The Human Genome Project : Childhood's End
, 2000 Kenta Nakai, Tetsushi Yada
openalex +2 more sources
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
Lessons from the Human Genome Project: Modesty, Honesty, and Realism. [PDF]
Front Genet, 2017 Emmert-Streib F, Dehmer M, Yli-Harja O.
europepmc +1 more source
Advanced Science, EarlyView.D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei +18 more
wiley +1 more source
Personal Genome Project UK (PGP-UK): a research and citizen science hybrid project in support of personalized medicine. [PDF]
BMC Med Genomics, 2018 PGP-UK Consortium.
europepmc +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Genetic dissection of seedling vigour in a diverse panel from the 3,000 Rice (Oryza sativa L.) Genome Project. [PDF]
Sci Rep, 2019 Chen K +8 more
europepmc +1 more source
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source