Results 31 to 40 of about 1,144,164 (329)
Mutational signatures of ionizing radiation in second malignancies
Nature Communications, 2016 Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati +32 more
doaj +1 more source
Virulence, 2021 Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological ...
Laura E. Hernández-Juárez +7 more
doaj +1 more source
Draft Genome Sequences of 1,183 Salmonella Strains from the 100K Pathogen Genome Project. [PDF]
, 2017 Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This is the public release of 1,183 Salmonella draft genome sequences as part of the 100K Pathogen Genome Project.
Arabyan, Narine +14 more
core +1 more source
Nature Communications, 2017 Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati +32 more
doaj +1 more source
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Reports, 2016 Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien +36 more
doaj +1 more source
Genome maps across 26 human populations reveal population-specific patterns of structural variation. [PDF]
, 2019 Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in ...
Cao, Han +25 more
core +2 more sources
Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape
Molecular Systems Biology, 2010 Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise +2 more
doaj +1 more source
REAPR: a universal tool for genome assembly evaluation. [PDF]
, 2013 Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked.
Berriman, Matthew +5 more
core +2 more sources
The driver landscape of sporadic chordoma
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
doaj +1 more source
Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells
Frontiers in Cell and Developmental Biology, 2023 The potential of mesenchymal stem cells (MSCs) for tissue repair and regeneration has garnered great attention. While MSCs are likely to interact with microbes at sites of tissue damage and inflammation, like in the gastrointestinal system, the ...
Nuradilla Mohamad-Fauzi +12 more
doaj +1 more source