Results 31 to 40 of about 5,973,095 (357)
Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses
Biomolecules, 2023 Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxidative
Hao-Wen Hsiao +2 more
doaj +1 more source
Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population
Human Genome Variation, 2021 Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi +7 more
doaj +1 more source
Scientific Reports, 2021 The spread of SARS-CoV-2 created a pandemic crisis with > 150,000 cumulative cases in > 65 countries within a few months. The reproductive number (R) is a metric to estimate the transmission of a pathogen during an outbreak.
D J Darwin R. Bandoy, Bart C. Weimer
doaj +1 more source
Briefings in Functional Genomics and Proteomics, 2008 The medaka Oryzias latipes is a small egg-laying freshwater teleost, and has become an excellent model system for ecotoxicology, developmental genetics, genomics and evolutionary biology studies. A high-quality draft genome sequence (700 Mb) of the medaka inbred strain, Hd-rR, has now been completed. In this review, we present an overview of the medaka
Hiroyuki Takeda, Daisuke Kobayashi
openaire +3 more sources
The Cancer Genome Atlas Pan-Cancer analysis project
Nature Genetics, 2013 Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer ...
J. Weinstein +8 more
semanticscholar +1 more source
Molecular tools to monitor health and disease – and lucky coincidences
Upsala Journal of Medical Sciences, 2022 Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease.
Ulf Landegren
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MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads
bioRxiv, 2023 Background PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb) and highly accurate (> Q20). Because of these properties, they have revolutionised genome assembly leading to more accurate and contiguous genomes.
Marcela Uliano-Silva +9 more
semanticscholar +1 more source
Deciphering Signatures of Mutational Processes Operative in Human Cancer
Cell Reports, 2013 The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov +4 more
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Virulence, 2021 Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological ...
Laura E. Hernández-Juárez +7 more
doaj +1 more source