Results 41 to 50 of about 5,973,095 (357)
Mutational signatures of ionizing radiation in second malignancies
Nature Communications, 2016 Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati +32 more
doaj +1 more source
Genome maps across 26 human populations reveal population-specific patterns of structural variation. [PDF]
, 2019 Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in ...
Cao, Han +25 more
core +2 more sources
Commentary: The Materials Project: A materials genome approach to accelerating materials innovation
, 2013 Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org), a core program of the Materials Genome Initiative that uses high ...
Anubhav Jain +10 more
semanticscholar +1 more source
Nature Communications, 2017 Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati +32 more
doaj +1 more source
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Reports, 2016 Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien +36 more
doaj +1 more source
The Human Genome Project [PDF]
Journal of the Royal Society of Medicine, 2005 On 14 April 2003 the US Human Genome Research Institute announced that scientists had just clipped into place the very last piece in the colossal jigsaw of human DNA. The next day's newspapers reminded us that, whilst it was early days yet, a host of diseases from eczema to dementia could one day be history.
openaire +3 more sources
Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape
Molecular Systems Biology, 2010 Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise +2 more
doaj +1 more source
Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells
Frontiers in Cell and Developmental Biology, 2023 The potential of mesenchymal stem cells (MSCs) for tissue repair and regeneration has garnered great attention. While MSCs are likely to interact with microbes at sites of tissue damage and inflammation, like in the gastrointestinal system, the ...
Nuradilla Mohamad-Fauzi +12 more
doaj +1 more source
Complete genome sequence of Spirosoma linguale type strain (1). [PDF]
, 2010 Spirosoma linguale Migula 1894 is the type species of the genus. S. linguale is a free-living and non-pathogenic organism, known for its peculiar ringlike and horseshoe-shaped cell morphology. Here we describe the features of this organism, together with
Brettin, Thomas +36 more
core +1 more source
Are we there yet? : reliably estimating the completeness of plant genome sequences [PDF]
, 2016 Genome sequencing is becoming cheaper and faster thanks to the introduction of next-generation sequencing techniques. Dozens of new plant genome sequences have been released in recent years, ranging from small to gigantic repeat-rich or polyploid genomes.
Ruttink, Tom +2 more
core +3 more sources