Results 61 to 70 of about 1,168,334 (239)

Biological Machine Learning Combined with Campylobacter Population Genomics Reveals Virulence Gene Allelic Variants Cause Disease

Microorganisms, 2020
Highly dimensional data generated from bacterial whole-genome sequencing is providing an unprecedented scale of information that requires an appropriate statistical analysis framework to infer biological function from populations of genomes.
DJ Darwin R. Bandoy, Bart C. Weimer
doaj   +1 more source

Personal genomes in progress: from the Human Genome Project to the Personal Genome Project

Dialogues in Clinical Neuroscience, 2010
The cost of a diploid human genome sequence has dropped from about $70M to $2000 since 2007--even as the standards for redundancy have increased from 7x to 40x in order to improve call rates. Coupled with the low return on investment for common single-nucleotide polylmorphisms, this has caused a significant rise in interest in correlating genome ...
Lunshof, J., Bobe, J., Aach, J., Angrist, M., Thakuria, J., Vorhaus, D., Hoehe, M., Church, G.   +7 more
openaire   +5 more sources

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

eLife, 2014
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are ...
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell   +52 more
doaj   +1 more source

Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region

Scientific Reports, 2023
Narcolepsy type 1 (NT1) is caused by a loss of hypothalamic orexin-producing cells, and autoreactive CD4+ and CD8+ T cells have been suggested to play a role in the autoimmune mechanism.
Kugui Yoshida-Tanaka, Mihoko Shimada, Yoshiko Honda, Akihiro Fujimoto, Katsushi Tokunaga, Makoto Honda, Taku Miyagawa   +6 more
doaj   +1 more source

Genome sequencing project has begun on two plant trypanosomatids (Phytomonas) [PDF]

, 2010
Some trypanosomatids are responsible for wilt in tropical crops, such as hartrot disease in the coconut palm. They have a major economic impact in Latin America and the Caribbean.
Artiguenave, Françoise, Aury, Jean-Marc, Couloux, Arnaud, Da Silva, Corinne, Dollet, Michel, Fabre, Sandrine, Jaillon, Olivier, Noël, Benjamin, Poulain, Julie, Wincker, Patrick   +9 more
core  

Nutritional Stress Leads to Persistence and Persister-like Growth in Staphylococcus aureus

Pathogens
Staphylococcus aureus is a versatile zoonotic pathogen capable of causing a wide range of infections. Due to the organism’s ability to persist, recalcitrant and recurring infections are a major concern for public and animal health.
Katie R. Risoen, Claire A. Shaw, Bart C. Weimer   +2 more
doaj   +1 more source

Case Report: Shift from Aggressive Periodontitis to Feline Chronic Gingivostomatitis Is Linked to Increased Microbial Diversity

Pathogens
Aggressive Periodontitis (AP) and Feline Chronic Gingivostomatitis (FCGS) are two oral inflammatory diseases in cats with unknown etiology. Both conditions present with severe inflammation of the oral cavity and in FCGS it is found with additional ...
Claire A. Shaw, Maria Soltero-Rivera, Rodrigo Profeta, Bart C. Weimer   +3 more
doaj   +1 more source

Artificial and Natural Genetic Information Processing [PDF]

, 2017
Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core  

Secondary (additional) findings from the 100,000 Genomes Project: Disease manifestation, health care outcomes, and costs of disclosure [PDF]

, 2023
Joshua Nolan, James Buchanan, John Taylor, João Rafael Almeida, Tina Bedenham, Edward Blair, Suzanne Broadgate, Samantha Butler, A. Cazeaux, Judith Craft, Treena Cranston, Gillian Crawford, Jamie I. Forrest, Jessica Gabriel, Elaine George, Donna Gillen, Ash Haeger, Jillian Hastings Ward, Lara Hawkes, Claire Hodgkiss, J. E. Hoffman, Alan Jones, Fredrik Karpe, Dalia Kasperavičiūtė, Erika Kovacs, S. E. A. Leigh, Elizabeth Limb, Anjali Lloyd-Jani, Javier Ferreiros, Anneke Lucassen, C J McFARLANE, Anthony W. O’Rourke, Emily Pond, Catherine Sherman, Helen Stewart, Ellen Thomas, Simon Thomas, Tessy Thomas, Kate Thomson, Hannah Wakelin, Susan Walker, Melanie Watson, Eleanor Williams, Elizabeth Ormondroyd   +43 more
openalex   +1 more source

Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis

Bacteria
The cat oral microbiome plays an important role in maintaining host health, yet little is known about how to apply microbial data in a clinical setting.
Claire A. Shaw, Maria Soltero-Rivera, Rodrigo Profeta, Bart C. Weimer   +3 more
doaj   +1 more source