Results 211 to 220 of about 81,508 (252)

Genome architecture, rearrangements and genomic disorders

Trends in Genetics, 2002
An increasing number of human diseases are recognized to result from recurrent DNA rearrangements involving unstable genomic regions. These are termed genomic disorders, in which the clinical phenotype is a consequence of abnormal dosage of gene(s) located within the rearranged genomic fragments.
Paweł, Stankiewicz, James R, Lupski
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Genome Rearrangements and Sorting by Reversals

SIAM Journal on Computing, 1996
Summary: Sequence comparison in molecular biology is in the beginning of a major paradigm shift -- a shift from gene comparison based on local mutations (i.e., insertions, deletions, and substitutions of nucleotides) to chromosome comparison based on global rearrangements (i.e., inversions and transpositions of fragments).
Vineet Bafna, Pavel A. Pevzner
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Phylogenetic Invariants for Genome Rearrangements

Journal of Computational Biology, 1999
We review the combinatorial optimization problems in calculating edit distances between genomes and phylogenetic inference based on minimizing gene order changes. With a view to avoiding the computational cost and the "long branches attract" artifact of some tree-building methods, we explore the probabilization of genome rearrangement models prior to ...
David Sankoff, Mathieu Blanchette
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TWO NOTES ON GENOME REARRANGEMENT

Journal of Bioinformatics and Computational Biology, 2003
A central problem in genome rearrangement is finding a most parsimonious rearrangement scenario using certain rearrangement operations. An important problem of this type is sorting a signed genome by reversals and translocations (SBRT). Hannenhalli and Pevzner presented a duality theorem for SBRT which leads to a polynomial time algorithm for sorting ...
Michal Ozery-Flato, Ron Shamir
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Hybridization and Genome Rearrangement

1999
We infer post-hybridization rearrangements in a hybrid genome, given the gene orders on its chromosomes and some knowledge of the two parent genomes. We study this in two biologically and computationally different contexts, genome fusion and interspecific fertilization.
Nadia El-Mabrouk, David Sankoff
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Genome rearrangements of rotaviruses

1996
Rotaviruses (and other members of the Reoviridae family) undergo rearrangements of their genomes. This review describes evidence of rearranged genomes in rotaviruses. Their structure and functions are reviewed. Possible mechanisms of their emergence are discussed, and the significance of genome rearrangements for viral evolution is considered.
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Genome Rearrangement: A Planning Approach

Proceedings of the AAAI Conference on Artificial Intelligence, 2010
Evolutionary trees of species can be reconstructed by pairwise comparison of their entire genomes. Such a comparison can be quantified by determining the number of events that change the order of genes in a genome. Earlier Erdem and Tillier formulated the pairwise comparison of entire genomes as the problem of planning rearrangement ...
Tansel Uras, Esra Erdem 0001
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Genome Rearrangements with Partially Ordered Chromosomes

Journal of Combinatorial Optimization, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chunfang Zheng, David Sankoff
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A Unifying View of Genome Rearrangements

2006
Genome rearrangements have been modeled by a variety of operations such as inversions, translocations, fissions, fusions, transpositions and block interchanges. The double cut and join operation, introduced by Yancopoulos et al., allows to model all the classical operations while simplifying the algorithms.
Bergeron, Anne, Mixtacki, Julia, Stoye, Jens   +2 more
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Genome Rearrangement Analysis: Cut and Join Genome Rearrangements and Gene Cluster Preserving Approaches

2017
Genome rearrangements are mutations that change the gene content of a genome or the arrangement of the genes on a genome. Several years of research on genome rearrangements have established different algorithmic approaches for solving some fundamental problems in comparative genomics based on gene order information.
Tom, Hartmann, Martin, Middendorf, Matthias, Bernt   +2 more
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