Finding local genome rearrangements [PDF]
Algorithms for Molecular Biology, 2018 Background The double cut and join (DCJ) model of genome rearrangement is well studied due to its mathematical simplicity and power to account for the many events that transform gene order.
Pijus Simonaitis, Krister M. Swenson
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A New Algorithm for Identifying Genome Rearrangements in the Mammalian Evolution [PDF]
Frontiers in Genetics, 2019 Genome rearrangements are the evolutionary events on level of genomes. It is a global view on evolution research of species to analyze the genome rearrangements.
Juan Wang +4 more
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Genetic Markers of Genome Rearrangements in Helicobacter pylori [PDF]
Microorganisms, 2021 Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements.
Mehwish Noureen +2 more
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R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements. [PDF]
PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
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Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants [PDF]
Scientific Reports, 2021 Genome stability in radioresistant bacterium Deinococcus radiodurans depends on RecA, the main bacterial recombinase. Without RecA, gross genome rearrangements occur during repair of DNA double-strand breaks. Long repeated (insertion) sequences have been
Jelena Repar +3 more
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Deciphering complex breakage-fusion-bridge genome rearrangements with Ambigram [PDF]
Nature Communications, 2023 Breakage-fusion-bridge (BFB) is a complex rearrangement that leads to tumor malignancy. Existing models for detecting BFBs rely on the ideal BFB hypothesis, ruling out the possibility of BFBs entangled with other structural variations, that is, complex ...
Chaohui Li +4 more
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Programmed genome rearrangements in ciliates. [PDF]
Cell Mol Life Sci, 2020 AbstractCiliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex.
Rzeszutek I +2 more
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Genome rearrangements and phylogeny reconstruction in Yersinia pestis [PDF]
PeerJ, 2018 Genome rearrangements have played an important role in the evolution of Yersinia pestis from its progenitor Yersinia pseudotuberculosis. Traditional phylogenetic trees for Y.
Olga O. Bochkareva +7 more
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The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements. [PDF]
PLoS Genetics, 2020 In Paramecium tetraurelia, a large proportion of the germline genome is reproducibly removed from the somatic genome after sexual events via a process involving small (s)RNA-directed heterochromatin formation and DNA excision and repair.
Augustin de Vanssay +5 more
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A comparison of the Caulobacter NA1000 and K31 genomes reveals extensive genome rearrangements and differences in metabolic potential [PDF]
Open Biology, 2014 The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4°C with a doubling ...
Kurt Ash +5 more
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