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Finding local genome rearrangements [PDF]
Algorithms for Molecular Biology, 2018 Background The double cut and join (DCJ) model of genome rearrangement is well studied due to its mathematical simplicity and power to account for the many events that transform gene order.
Pijus Simonaitis, Krister M. Swenson
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Genome-wide detection of spontaneous chromosomal rearrangements in bacteria. [PDF]
PLoS ONE, 2012 Genome rearrangements have important effects on bacterial phenotypes and influence the evolution of bacterial genomes. Conventional strategies for characterizing rearrangements in bacterial genomes rely on comparisons of sequenced genomes from related ...
Song Sun +4 more
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Genetic Markers of Genome Rearrangements in Helicobacter pylori
Microorganisms, 2021 Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements.
Mehwish Noureen +2 more
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A New Algorithm for Identifying Genome Rearrangements in the Mammalian Evolution
Frontiers in Genetics, 2019 Genome rearrangements are the evolutionary events on level of genomes. It is a global view on evolution research of species to analyze the genome rearrangements.
Juan Wang +4 more
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A comparison of the Caulobacter NA1000 and K31 genomes reveals extensive genome rearrangements and differences in metabolic potential [PDF]
Open Biology, 2014 The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4°C with a doubling ...
Kurt Ash +5 more
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Are there rearrangement hotspots in the human genome? [PDF]
PLoS Computational Biology, 2007 In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome.
Max A Alekseyev, Pavel A Pevzner
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Frontiers in GeneticsIntroductionIndividuals with balanced chromosomal rearrangements are at an increased risk for infertility, recurrent miscarriages, and the birth of infants with congenital malformations.
Xiaohang Hu +9 more
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On the Complexity of Some Variations of Sorting by Transpositions [PDF]
Journal of Universal Computer Science, 2020 One of the main challenges in Computational Biology is to find the evolutionary distance between two organisms. In the field of comparative genomics, one way to estimate such distance is to find a minimum cost sequence of rearrangements (large scale ...
Alexsandro Alexandrino +3 more
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Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes. [PDF]
PLoS Genetics, 2005 Rearrangements of our genome can be responsible for inherited as well as sporadic traits. The analyses of chromosome breakpoints in the proximal short arm of Chromosome 17 (17p) reveal nonallelic homologous recombination (NAHR) as a major mechanism for ...
James R Lupski, Pawel Stankiewicz
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PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
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